Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 932-124-4 | CAS number: -
Carcinogenicity
Administrative data
Description of key information
SFL is not expected to pose a risk of carcinogenicity.
Key value for chemical safety assessment
Justification for classification or non-classification
No carcinogenicity classification is warranted for SFL according to either the DSD or CLP based on evidence from genotoxicity, repeat dose studies and long term human studies performed on calcium carbonate.
Additional information
All calcium carbonate toxicity studies are considered to be relevant to sugar factory lime (SFL) based on the fact that SFL is primarily composed of calcium carbonate (61.8 - 95.6 %w/w)and other calcium salts. SFL is not classified for human health. Of its components, only calcium oxalate is classified as acutely toxic via the oral and dermal routes (category 4); however, it is present below the concentration limit that would result in classification of SFL. As a result, it is considered that the properties of SFL are governed by those of calcium carbonate.
There are no lifetime animal studies available on calcium carbonate in order to directly investigate its possible carcinogenic activity. However, calcium carbonate gave negative results in the in vitro genotoxicity studies and in repeat dose studies with calcium carbonate (nano) there is no evidence that calcium carbonate is able to induce hyperplasia or pre-neoplastic lesions. Furthermore, the long term human data does not provide any indications of carcinogenicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
