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Diss Factsheets

Physical & Chemical properties

Water solubility

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Endpoint:
water solubility
Type of information:
other: handbook data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
A method is not specified.
Remarks on result:
other: Glyoxylic Acid is very soluble in water, based on literature data reported in Römpp Chemie Lexikon
Executive summary:

Glyoxylic Acid is very soluble in water, based on literature data reported in Römpp Chemie Lexikon

Endpoint:
water solubility
Type of information:
other: handbook data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
No method specified.
Remarks on result:
other: Glyoxylic Acid is very soluble in water.
Endpoint:
water solubility
Type of information:
other: Handbook data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
A method is not indicated.
Remarks on result:
other: Glyoxylic Acid is very soluble in water.
Executive summary:

Glyoxylic Acid is very soluble in water, based on Handbook data from CRC Handbook of Chemistry and Physics

Endpoint:
water solubility
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
QSAR prediction
Qualifier:
no guideline followed
Principles of method if other than guideline:
Calculation by using WATERNT program (V. 1.01) from Epiweb 4.0
GLP compliance:
no
Water solubility:
1 000 000 mg/L
Temp.:
25 °C
Remarks on result:
other: calculated

Purpose

The purpose of this expert statement was to evaluate the water solubility of Glyoxylic Acid.

Guidelines

The study procedures described in this report are based on the following guideline: European Community Directive 92/69 EEC, part A, methods for the determination of physico-chemical properties, A.6 “water solubility “, EEC publication no L383 A, December 1992.

Statement

The test method for the determination of the water solubility of a test substance as described in Test Guideline A.6 of EC Directive 92/69/EEC was replaced by a theoretical based evaluation. In accordance with Regulation 1907/2006/EC Annex XI the study does not need to be performed as water solubility can be determined based on exisiting data and application of (Q)SAR Models. Since Glyoxylic Acid is marketed as a 50% solution in water a water solubility of > 1000 g/L can be assumed. Literature data already indicates that Glyoxylic Acid is very soluble in water. In the present study water solubility of Gloxylic Acid was calculated with the WATERNT program Version 1.01 (2008) from the Epiweb 4.0. and resulted in value of 1*10^6 mg/L at 25°C.

Executive summary:

The water solubility of Gloxylic Acid was calculated with the WATERNT program and resulted in a value of 1e06 mg/L at 25°C.

Endpoint:
water solubility
Type of information:
other: Handbook data
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Principles of method if other than guideline:
A method is not specified.
Remarks on result:
other: Glyoxylic Acid is very soluble in water
Executive summary:

Glyoxylic Acid is very soluble in water, based on Handbook data from the Merck Index

Description of key information

The water solubility of Gloxylic Acid was calculated with the WATERNT program and resulted in a value of 1e06 mg/L at 25°C.

Key value for chemical safety assessment

Additional information

Qualitative data on the water solubility of Glyoxylic Acid 50% is available from literature, indicating very high solubility in water. Additionally the water solubility of Glyoxylic Acid 50% was calculated as 1e06 mg/L by using WATERNT program (2008) from Epiweb 4.0, which is supported by the available literature data.