Registration Dossier
Registration Dossier
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EC number: 206-058-5 | CAS number: 298-12-4
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- other: Bibliographic peer reviewed data
- Adequacy of study:
- weight of evidence
- Study period:
- 1985
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 3.3
- Temp.:
- 25 °C
- Executive summary:
The acid-base constant of Glyoxylic Acid is 3.3 as reported in Lange´s Handbook of Chemistry.
- Endpoint:
- dissociation constant
- Type of information:
- other: Handbook
- Adequacy of study:
- weight of evidence
- Study period:
- 1989
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 4.7
- Temp.:
- 25 °C
- Executive summary:
The acid-base constant of Glyoxylic Acid 50% is 4.7, based on literature data from Ullmann´s encyclopedia.
- Endpoint:
- dissociation constant
- Type of information:
- other: handbook
- Adequacy of study:
- weight of evidence
- Study period:
- 1996
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- not applicable
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 4.6
- Temp.:
- 25 °C
- Executive summary:
The acide base constant of Glyoxylic Acid is 4.6 as reported in the Merck Index.
- Endpoint:
- dissociation constant
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- QSAR prediction
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Calculation by using SPARC Performance Automated Reasoning in Chemistry (Release w4.5.1529-s4.5.1529; september 2009)
- GLP compliance:
- not specified
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- 3.12
- Temp.:
- 25 °C
- Executive summary:
By using SPARC Performance Automated Reasoning in Chemistry (V 4.2) the dissociation constant of Glyoxylic Acid was calculated and resulted in pKa of 3.12. For detailed information on the dissociation properties of Glyoxylic Acid see attached file.
Referenceopen allclose all
The acid-base constant of Glyoxylic Acid is 3.3
The acid-base constant of Glyoxylic Acid is 4.6.
Description of key information
The dissociation constant of Glyoxylic Acid 50% is in the range from 3.12-4.7.
Key value for chemical safety assessment
Additional information
Data on the dissociation constant of Glyoxylic Acid 50% is available from handbook literature and values of 3.3, 4.6 and 4.7 are reported. Additionally the dissociation constant of Glyoxylic Acid 50% was calculated as 3.12 by using SPARC Performance Automated Reasoning in Chemistry (V 4.2). The calculated value for the dissociation constant is in line with the reported values from handbook data.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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