Registration Dossier
Registration Dossier
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EC number: 205-746-2 | CAS number: 149-74-6
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
- Principles of method if other than guideline:
- No guideline is specified; a relatively brief report is given. The neat material was applied to the intact belly skin of rabbits for 15 or 30 seconds, 1 or 2 minutes.
- GLP compliance:
- no
Test material
- Reference substance name:
- Dichloro(methyl)(phenyl)silane
- EC Number:
- 205-746-2
- EC Name:
- Dichloro(methyl)(phenyl)silane
- Cas Number:
- 149-74-6
- Molecular formula:
- C7H8Cl2Si
- IUPAC Name:
- dichloro(methyl)(phenyl)silane
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 15 sec
30 sec
1 min
2 min - Observation period:
- not stated
- Number of animals:
- not stated - possibly one
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: slight erythema and necrosis
- Time point:
- other: 15 seconds
- Irritation parameter:
- other: marked necrosis
- Time point:
- other: 1 minute
Any other information on results incl. tables
15 seconds slight erythema and necrosis
30 seconds slight erythema and necrosis
1 minute marked necrosis
2 minutes marked necrosis
Applicant's summary and conclusion
- Conclusions:
- A limited report of a study without guideline or GLP compliance recorded slight necrosis and marked necrosis to rabbit skin, following contact for 15 seconds and 1 minute, respectively, with the neat material.
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