Tributylamine

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1923

Reliability:

3 (not reliable)

Rationale for reliability incl. deficiencies:

significant methodological deficiencies

Cross-reference

Reason / purpose for cross-reference:

reference to same study

Data source

Reference

Reference Type:

publication

Title:

Unnamed

Year:

1923

Report date:

1923

Materials and methods

Principles of method if other than guideline:

other: acute toxicity testing - subcutaneous application

GLP compliance:

no

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Tributylamine

EC Number:

203-058-7

EC Name:

Tributylamine

Cas Number:

102-82-9

Molecular formula:

C12H27N

IUPAC Name:

tributylamine

Details on test material:

- Name of test material (as cited in study report): Tributylamin

Test animals

Species:

rat

Strain:

other: white

Sex:

not specified

Administration / exposure

Route of administration:

subcutaneous

Vehicle:

not specified

Doses:

no data

No. of animals per sex per dose:

6

Control animals:

not specified

Results and discussion

Effect levels

Effect levels 1

Sex:

not specified

Dose descriptor:

LDLo

Effect level:

ca. 310 - 390 mg/kg bw

Remarks on result:

other: mean: 350 mg/kg bw

Effect levels 2

Sex:

not specified

Dose descriptor:

LD100

Effect level:

780 mg/kg bw

Remarks on result:

other: within 6 min after application

Mortality:

see table remarks on results

Clinical signs:

restlessness, reflex excitability, increased pulse rate, increased  respiration during the excitant state, dyspnea, convulsions of the  medullary type at first, later spinal, followed by depression, slowing of the  pulse and respiration, marked cyanosis of mucosa and tongue, coma, and  death.
Similar symptoms were noted in rabbits.

Gross pathology:

Collapsed lungs, congested and cyanotic viscera, heart dilatation, still  active intestinal peristalsis, dark discoloration of the blood.

Any other information on results incl. tables

The dose is given as 0.4 to 0.5 ml/kg bw respective mean 0.45 ml/ kg bw (conversion to mg/kg bw was done using the density d= 0.78 g/ccm).

[mg/kg bw]	number of animals used	mortality [%]
1560 -1950	2	100
1170	1	100
390 -780	13	69
234 -312	6	0

Applicant's summary and conclusion

Conclusions:

The data presented in this study are insufficient and do not fit the requirements for a definite interpretation of the results.

Executive summary:

Testing acute toxicity in rats led to a minimal fatal dose (LDLo) in the range of 310 to 390 mg test substance (Tributylamin) per kg bw and a fatal dose (LD100) of 780 mg/kg bw after subcutaneous application (Hanzlik, 1923).