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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Non-GLP, slightly deviating from guideline

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 402 (Acute Dermal Toxicity)
Deviations:
yes
Remarks:
Groups of three animals (rabbits), except the high dose group of two animals, were exposed topically to one dermal dose of test substance.
Principles of method if other than guideline:
Groups of three animals, except the high dose group of two animals, were exposed topically to one dermal dose of test substance. Animals were observed during a period of 14 days.
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Allyl heptanoate
EC Number:
205-527-1
EC Name:
Allyl heptanoate
Cas Number:
142-19-8
Molecular formula:
C10H18O2
IUPAC Name:
allyl heptanoate

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Duration of exposure:
14 days
Doses:
313 mg/kg, 625 mg/kg, 1250 mg/kg and the max dose : 5000 mg/kg
No. of animals per sex per dose:
2 for the max dose and 3 for each dose
Control animals:
not specified

Results and discussion

Preliminary study:
none
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
810 mg/kg bw
Mortality:
1250 mg/kg lethal (3/3 deaths)
5000 mg/kg lethal (2/2 deaths)
Clinical signs:
other: at 5000 mg/kg : severe diarrhea in 2/2 at 1250 mg/kg : diarrhea in 1/3 and ataxia in 2/3
Other findings:
0.313 g/kg no effects
0.625 g/kg nonspecific effects (0 deaths)

Any other information on results incl. tables

Route Dose mg/Kg Death/ nb. of Animals Obseravation Day
1 2 3 4 5 6 7 8 9 10 11 12 13 14
Dermal 313 0/3 0 0 0 0 0 0 0 0 0 0 0 0 0 0
625 0/3 0 0 0 0 0 0 0 0 0 0 0 0 0 0
1250 3/3 0 0 1 0 1 0 0 0 1 0 0 0 0 0
5000 2/2 2 0 0 0 0 0 0 0 0 0 0 0 0 0

Applicant's summary and conclusion

Interpretation of results:
other: Toxicity Category III
Executive summary:

The acute dermal toxicity of allyl heptanoate was assessed in an acute dermal toxicity study performed equivalent or similar to OECD Guideline 402. Groups consisting of 3 rabbits each, except the high dose group of 2 animals, were treated topically with a single dose of 313, 625, 1250 and 5000 mg/kg bw of the target substance. Animals were observed during a period of 14 days. No mortality occurred at 313 and 625 mg /kg bw. All animals died at 1250 and 5000 mg/kg bw. The calculated LD50 value was 810 mg/kg bw.

The available data on acute dermal toxicity meet the criteria for Acute Tox. Cat. 3 (H311) according to Regulation (EC) 1272/2008.