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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
experimental study
Adequacy of study:
key study
Study period:
Single administration, duration not reported
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Purity and chemical physical properties of the test substance not mentione, strain, sex, and age of the test animals not mentioned, environmental contiditons and feeding not mentioned.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
other: Federal Register 26(155):7336, 12 August 1961
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
not specified
Details on test material:
Dechlorane Plus, tested as supplied

Test animals

Species:
rabbit
Strain:
not specified
Sex:
not specified
Details on test animals and environmental conditions:
No details on environmental conditions reported

Administration / exposure

Type of coverage:
not specified
Vehicle:
not specified
Details on dermal exposure:
Application to intact and abraded skin, no further details on dermal exposure reported
Duration of exposure:
Not reported
Doses:
500, 1,000, 2,000, 4,000, 8,000 mg/kg bodyweight
No. of animals per sex per dose:
2 rabbits with intact skin and 2 rabbits with abraded skin per dose level, sex not reported
Control animals:
no
Details on study design:
No further details reported
Statistics:
none

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LD0
Effect level:
> 8 000 mg/kg bw
Based on:
act. ingr.
Remarks on result:
other: no effects observed up to the highest dose
Mortality:
none
Clinical signs:
none reported
Body weight:
not recorded
Gross pathology:
not recorded
Other findings:
no other findings observed

Any other information on results incl. tables

dose       No rabbits       Mortality       No rabbits       Mortality

mg/kg     skin intact                            skin abraded

500               2                     0                     2                     0

1,000            2                     0                     2                     0

2,000            2                     0                     2                     0

4,000            2                     0                     2                     0

8,000            2                     0                     2                     0

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Nontoxic according to EU criteria
Executive summary:

Two rabbits each were administered Dechlorane Plus once dermally on intact or abraded skin at dose levels of 500, 1,000, 2,000, 4,000, or 8,000 mg/kg bw for an unspecified period of time. No mortality was observed. The NOEL was determined at 8,000 mg/kg bw. Dechlorane Plus was not toxic upon dermal application.