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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Purity and physical chemical properties of test substance not given, age of animals not given, concentration in air not analytically verified.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1975
Report Date:
1975

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Exposure for 4 hours to one concentration with 14 days postdosing observation period, one group of 5 males and 5 females, particle size distribution determined, mortality, bodyweights, and gross pathology recorded
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder
Details on test material:
Dechlorane Plus 25: particle size distribution 56.8% at 1-5 µm, 10.2% at 6-10 µm, 14.8% at 11-25 µm, 18.2% at >25 µm.

Test animals

Species:
rat
Strain:
other: Charles River
Sex:
male/female
Details on test animals and environmental conditions:
No further details reported.

Administration / exposure

Route of administration:
inhalation: dust
Type of inhalation exposure:
not specified
Vehicle:
clean air
Details on inhalation exposure:
Particle size distribution 56.8% at 1-5 µm, 10.2% at 6-10 µm, 14.8% at 11-25 µm, 18.2% at >25 µm, exposure for 4 hours, no further details reported.
Analytical verification of test atmosphere concentrations:
no
Duration of exposure:
4 h
Concentrations:
2.25 mg/l
No. of animals per sex per dose:
5 males and 5 females
Control animals:
no
Details on study design:
4 hours exposure, 14 days postexposure observation time, mortality, bodyweight, and gross pathology were recorded. No further details reported.
Statistics:
none

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LC0
Effect level:
> 2.25 mg/L air (nominal)
Based on:
act. ingr.
Exp. duration:
4 h
Remarks on result:
other: no mortality, no effects on bodyweights, no changes in gross pathology
Mortality:
none
Clinical signs:
none reported
Body weight:
no effects
Gross pathology:
no effects
Other findings:
no other findings

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
Not toxic at a concentration of 2.25 mg/l in air as dust upon 4 hours of inhalation.
Executive summary:

Groups of 5 male and 5 female rats were exposed by inhalation to Dechlorane Plus 25 at a concentration of 2.25 mg/l as dust in air for 4 hours. No treatment-related effects were observed. The NOEL was determined at 2.25 mg/l. Dechlorane Plus 25 was not toxic by inhalation.