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Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
single administration
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study with acceptable restrictions
Remarks:
Klimisch Rating 2, purity and physicochemical properties of the test substance not given, age of test organism not given.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1971
Report Date:
1971

Materials and methods

Test guideline
Qualifier:
equivalent or similar to
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Deviations:
yes
Remarks:
signs of systemic toxicity besides mortality not recorded
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid - liquid: suspension
Details on test material:
Dechlorane Plus, tested as a 50% W/V suspension in water containing 0.5% tween 80

Test animals

Species:
rat
Strain:
Sherman
Sex:
male/female
Details on test animals and environmental conditions:
No details reported

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: water containing 0.5% tween 80
Details on oral exposure:
animals starved for 24 hours followed by single gavage administration
Doses:
1,500, 3,000, 6,000, 12,500, 25,000 mg/kg bodyweight
No. of animals per sex per dose:
3 males and 2 females per dose
Control animals:
no
Details on study design:
Administration followed by a 14 days postdose observation period, only mortality recorded, no recording of signs of systemic toxicity besides mortality
Statistics:
none

Results and discussion

Effect levels
Key result
Sex:
male/female
Dose descriptor:
LD0
Effect level:
> 25 000 mg/kg bw
Based on:
act. ingr.
Remarks on result:
other: no toxic effect observed
Mortality:
none
Clinical signs:
none reported
Body weight:
not determined
Gross pathology:
not determined
Other findings:
none reported

Any other information on results incl. tables

Dose level     Dose level       Day - Mortality

ml/kg              mg/kg              1       2       3       4       5       6       7       8       9       10      11     12     13      14     total

3.0               1,500               0       0       0       0       0       0       0       0       0        0        0       0       0        0       0 

6.0                  3,000              0       0       0       0       0       0       0       0       0        0        0       0       0        0       0

12.0               6,000              0       0       0       0       0       0       0       0       0        0        0       0       0        0       0

25.0              12,500              0       0       0       0       0       0       0       0       0        0        0       0       0        0       0   

50.0              25,000              0       0       0       0       0       0       0       0       0        0        0       0       0        0       0    

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Not toxic according to EU criteria, LD50 > 25000 kg/kg bw
Executive summary:

Groups of 3 male and 2 female rats were given Dechlorane Plus as suspension in aqueous methylcellulose once orally at dose levels of 1,500, 3,000, 6,000, 12,500, or 25,000 mg/kg bw by gavage and were observed for 14 days for mortality. No mortality occurred. The NOEL was determined at 25,000 mg/kg bw. Dechlorane Plus was nontoxic.