Registration Dossier
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EC number: 204-815-4 | CAS number: 126-97-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Based on the overall information available for thioglycolic acid, its salts and its main degradation (via oxidation) product, the substances can be considered as of low toxicity for aquatic species. The information available for the anionic form allows to conclude that the thioglycolate is harmful to Daphnia magna only. Acute ecotoxicity knowledge is strengthened by information existing on diammonium dithioglycolate which is the main degradation product of thioglycolic acid. Diammonium dithioglycolate occurs rapidly in the environment based on practical case (Devaux, 2003) and therefore this case is a good surrogate for the thioglycolate ecotoxicity. On this basis it can be concluded that the thioglycolate anion is neither toxic nor harmful for algae. Diammonium dithioglycolate data also exists for Daphnia and demonstrates that this form is neither toxic nor harmful for Daphnia. Additionally, it can be considered that the thioglycolate anion is of no concern for Daphnia based on its half-life in water. Nevertheless as valid experimental data exists on the thioglycolic acid, the applicant prefers to retain this result and concludes that thioglycolic acid is harmful to Daphnia.
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