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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Study period:
1974
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Methods applied similar to OECD404, report not detailed, no individual data
Cross-reference
Reason / purpose for cross-reference:
reference to same study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1974
Report date:
1974

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
24h exposure instead of 4 h
Principles of method if other than guideline:
-
GLP compliance:
no
Remarks:
performed before GLP guidelines

Test material

Constituent 1
Chemical structure
Reference substance name:
1,2-bis(2-methoxyethoxy)ethane
EC Number:
203-977-3
EC Name:
1,2-bis(2-methoxyethoxy)ethane
Cas Number:
112-49-2
Molecular formula:
C8H18O4
IUPAC Name:
2,5,8,11-tetraoxadodecane
Details on test material:
- Name of test material (as cited in study report): Triglykoldimethylether
- Analytical purity: > 99%
- physical state: clear colourless liquid

Test animals

Species:
rabbit
Strain:
other: Albino-Russian
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Hoechst AG own breed
- Strain: Albino Russian rabbits
- Weight at study initiation: 1,5-2,0 kg
- Age at study initiation: no data
- Diet: ERKA 8300 (Futtermittelwerk Robert Koch oHG, Hamm/Westf.) ad libitum
- Water ad libitum
- Acclimatization period: no data

ENVIRONMENTAL CONDITIONS
- Housing: single cages

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
not required
Amount / concentration applied:
0,5 ml of pure substance was applied.
Duration of treatment / exposure:
24 hours
Observation period:
24 hours post application
48 hours post application
72 hours post application
Number of animals:
6 rabbits
Details on study design:
TEST SITE:

- Shaved area: two neighboured positions, each 3 x 3 cm
- Preparation of skin area: one position only shaved, the other one abraded in addition.
- Area of exposure: 2.5 x 2.5 cm
- % coverage: 100 %
The substance was applied over the whole surface of a 2.5 x 2.5 cm gauze patch. The patches were fixed with adhesive tape to the prepared skinarea (ca. 2 x 9 cm2) and then covered with an occlusive PVC foil and further fixed with an elastic bandage.

SCORING SYSTEM:

According to guideline "Code of Federal Regulations, Title 21, Chapter 1, § 191.11, S. 243-244, 1972"

The classification was cunducted according to following evaluation classes:

< 2.................mildly irritant
2-5.................moderately irritant
> 6.................severely irritant

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
edema score
Basis:
animal #6
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
erythema score
Basis:
animal #6
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal #5
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
erythema score
Basis:
animal #5
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal #4
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
erythema score
Basis:
animal #4
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
erythema score
Basis:
animal #3
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
erythema score
Basis:
animal #2
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
edema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritation parameter:
erythema score
Basis:
animal #1
Time point:
24/48/72 h
Score:
0
Remarks on result:
no indication of irritation
Irritant / corrosive response data:
-
Other effects:
-

Any other information on results incl. tables

-

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
The test substance triethylene glycol dimethyl ether can be considered as non irritating to skin under the conditions of this Patch-test and according to criteria cited in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC) and the Code of Federal Regulations, Title 21, Chapter 1, § 191.11, S. 243-244, 1972.
Executive summary:

The test substance triethylene glycol dimethyl ether can be considered as non irritating to skin under the conditions of this Patch-test and according to criteria cited in the EU Dangerous Substances Directive (67/548/EEC) and in the EU Classification Labelling and Packaging Regulation (1272/2008/EC) and the Code of Federal Regulations, Title 21, Chapter 1, § 191.11, S. 243-244, 1972.