Registration Dossier
Registration Dossier
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EC number: 800-696-3 | CAS number: 78605-96-6
Endpoint summary
Administrative data
Description of key information
Several human repeat insult patch tests were conducted to determine the dermal sensitising potential for amyl cinnamaldehyde.
Additional information
No conclusive responses were found to indicate a notable sensitising potential for amyl cinnamic aldehyde in the human population although the human volunteer studies do identify several positive responders but at a low incidence consistent with the predictive response obtained from the LLNA. The predicted response determined from a murine local lymph node assay is that a very low potential for inducing a dermal sensitisation response in the human population is unlikely to exceed the threshold for classification of the substance as even a weak sensitiser. Although alpha-hexyl cinnamic aldehyde has been used as a positive control in sensitisation assays, there is no evidence that the structurally related amyl cinnamaldehyde has the same sensitising potential and cross -sensitivity investigations also indicate one does not induce a response from the other.
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