Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 817-668-1 | CAS number: 667899-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- The study was conducted between 27 August 2004 and 24 September 2004.
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Deviations:
- no
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- mixture of sewage, soil and natural water
- Details on inoculum:
- Standard activated sludge (sludge No. 160827), which was obtained from Chemical Biotesting Center of Chemicals Evaluation and Research Institute, Japan, on August 27th, 2004, and had been cultured and maintained in the laboratory.
- Duration of test (contact time):
- 28 d
- Initial conc.:
- 101.1 mg/L
- Based on:
- act. ingr.
- Details on study design:
- TEST CONDITIONS
- Test temperature: 25 degree celsius
- pH: 7.25
TEST SYSTEM
- Culturing apparatus: Coulometer, Ohkura Electric Co., Ltd. OM-2001A type
- Number of culture flasks: 3
- Measuring equipment: Data sampler, Asahi TechneionCo.,Ltd. DS-3SAMPLING
- Sampling frequency: 7, 14, 21, 28 d
CONTROL AND BLANK SYSTEM
- Inoculum blank: Yes
- Abiotic sterile control: Yes - Reference substance:
- aniline
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 60
- Sampling time:
- 28 d
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Under the test conditions, the test substance was considered to be readily biodegradable.
- Executive summary:
A study was conducted to determine the ready biodegradability of the substance according to OECD Guideline 301C (modified MITI test). Standard activated sludge was exposed to 101.1 mg/L of the test substance under aerobic conditions for 28 d in culture flasks. A reference substance (aniline), an abiotic control and inoculum blanks were maintained simultaneously. Sampling was performed on Day 7, 14, 21 and 28 and the % biodegradation was calculated based on oxygen consumption. The results showed that the biodegradation of the test substance was an average of 60% after 28 d. The degree of biodegradation of aniline was 67% in 7 d and 75% after 14 d, hence the study was considered to be valid. Under the study conditions, the substance was considered to be readily biodegradable (Koei, 2004).
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- The study was conducted between 6 June 2006 and 4 July 2006.
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.4-C (Determination of the "Ready" Biodegradability - Carbon Dioxide Evolution Test)
- Deviations:
- no
- GLP compliance:
- no
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge: From the aeration tank of a municipal sewage treatment plant, ARA Werdhölzli, 8048 Zürich, Switzerland
- Pretreatment: No - Duration of test (contact time):
- 28 d
- Initial conc.:
- 22.1 mg/L
- Based on:
- TOC
- Initial conc.:
- 21.8 mg/L
- Based on:
- TOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TEST CONDITIONS
- Composition of medium: Aerobic mineral salts medium, prepared with deionised water
- Test temperature: 22.0 ± 0.5°C
- pH: 7.4 ± 0.2
- pH adjusted: yes with NaOH or H2SO4
- Aeration of dilution water: with CO2-free air
- Suspended solids concentration: 30 mg/L
TEST SYSTEM
- Culturing apparatus: 2500 mL glass bottles containing 2000 mL test solution;
- Number of culture flasks/concentration: 2
- Method used to create aerobic conditions: aerated with CO2-free air and fitted to gas-absorbtion bottles containing 125 mL of 0.15 M NaOH
- Measuring equipment: Shimadzu 5050 TOC-Analyzer using the NPOC-mode
SAMPLING
- Sampling frequency: Days 0, 1, 3, 7, 10, 14, 17, 21, 24 and 28
CONTROL AND BLANK SYSTEM
- Inoculum blank: 2 replicates - Reference substance:
- benzoic acid, sodium salt
- Remarks:
- 20 mg/L (TOC)
- Key result
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 96
- Sampling time:
- 28 d
- Results with reference substance:
- The reference substance was degraded to 96.9% by Day 14.
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Under the study conditions, the substance was considered to be readily biodegradable.
- Executive summary:
A study was conducted to determine the ready biodegradability of the substance according to OECD Guideline 301B and EU Method C.4 -C, in a non-GLP set-up. Activated sludge from a municipal sewage treatment plant was exposed to the test substance at 22.1 mg/L (based on TOC level) under aerobic exposure conditions. An inoculum blank and a reference substance (sodium benzoate) were also maintained in this study. The biodegradability based on CO2 evolution of the test substance was calculated to be 96% of the theoretical value (ThCO2) after an incubation time of 28 days. The biodegradation of the test substance reached 84% at the end of the 10-d window. The positive control, sodium benzoate, reached 97% biodegradation after 14 d, thus confirming suitability of inoculum and test conditions. The calculated biodegradation based on DOC measurement reached 96% for the test substance and 99% for sodium benzoate. Under the study conditions, the substance was considered to be readily biodegradable (BASF, 2004).
Referenceopen allclose all
The test substance is readily biodegradable under conditions tested. The biodegradation was > 60% within 28 d and reached 84% at the end of the 10-day-window.
Table 1: Percentage biodegradation of test and reference substance.
Day | Test substance (% degradation) | Reference susbtance (% degradation) |
0 | 0.0 | 0.0 |
1 | 0.6 | 4.6 |
3 | 5.3 | 45.2 |
7 | 52.1 | 81.2 |
10 | 71.5 | 92.8 |
14 | 86.6 | 96.7 |
17 | 91.7 | 97.6 |
21 | 93.1 | 98.0 |
24 | 96.3 | 97.8 |
28 | 96.0 | 96.9 |
Description of key information
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
A study was conducted to determine the ready biodegradability of the substance according to OECD Guideline 301C (modified MITI test). Standard activated sludge was exposed to 101.1 mg/L of the test substance under aerobic conditions for 28 d in culture flasks. A reference substance (aniline), an abiotic control and inoculum blanks were maintained simultaneously. Sampling was performed on Day 7, 14, 21 and 28 and the % biodegradation was calculated based on oxygen consumption. The results showed that the biodegradation of the test substance was an average of 60% after 28 d. The degree of biodegradation of aniline was 67% in 7 d and 75% after 14 d, hence the study was considered to be valid. Under the study conditions, the substance was considered to be readily biodegradable (Koei, 2004).
A study was conducted to determine the ready biodegradability of the read-across substance CAS 68424 -31 -7 according to OECD Guideline 301B and EU Method C.4 -C. Activated sludge from a municipal sewage treatment plant was exposed to the test substance at 22.1 mg/L (based on TOC level) under aerobic exposure conditions. An inoculum blank and a reference substance (sodium benzoate) were also maintained in this study. The biodegradability based on CO2 evolution of the test substance was calculated to be 96% of the theoretical value (ThCO2) after an incubation time of 28 days. The biodegradation of the test substance reached 84% at the end of the 10-d window. The positive control, sodium benzoate, reached 97% biodegradation after 14 d, thus confirming suitability of inoculum and test conditions. The calculated biodegradation based on DOC measurement reached 96% for the test substance and 99% for sodium benzoate. Under the study conditions, the substance was considered to be readily biodegradable (BASF, 2006).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.