Registration Dossier
Registration Dossier
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EC number: 932-833-9 | CAS number: -
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
There are no reliable data describing the long-term toxicity of the
registered substance to fish. However, testing to determine long-term
toxicity of the registered substance to fish is not considered
appropriate on the grounds that:
- short-term toxicity of the substance to aquatic invertebrates is low,
- uptake of the substance by fish is low (Theil, 1987),
- both citric acid and iron are physiologically important for fish,
- any effects of ammonia can be assessed on the basis of extensive
existing information on its hazards to aquatic organisms.
Toxicity data with iron indicate long-term effects to lie in the range 1-10 mg/l, however these are mediated via the production of insoluble iron oxides and hydroxides. The effects are due to smothering or clogging of the gills or respiratory membranes rather than intrinsic toxicity. In addition, pH effects confound iron toxicity observed in the studies.
A 30-day EC10 value of 5.29 mg/l has been reported in the online disseminated dossier for ammonium sulfate (CAS: 7783-20-2) for sub-lethal effects on reproduction in Lepomis macrochirus. The value is adjusted to pH 8 and 25°C and isequivalent to a NOEC 0.076 mg un-ionized NH3/l.
There are no long-term effects studies with citric acid, however the substance is not expected to be toxic.
Theil, E. (1987) Ferritin: structure, gene regulation, and cellular function in animals, plants, and microorganisms.Ann. Rev. Biochem.56: 289–315.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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