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EC number: 619-020-1 | CAS number: 94361-06-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Solubility in organic solvents / fat solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- solubility in organic solvents / fat solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 23 Nov 1998 to 16 Dec 1998
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: CIPAC method MT 157.3 (water solubility: flask method)
- GLP compliance:
- yes
- Medium:
- other: Dichloromethane
- Solubility:
- 430 g/L
- Temp.:
- 25 °C
- Medium:
- acetone
- Solubility:
- 360 g/L
- Temp.:
- 25 °C
- Medium:
- ethyl acetate
- Solubility:
- 240 g/L
- Temp.:
- 25 °C
- Medium:
- other: Hexane
- Solubility:
- 1.3 g/L
- Temp.:
- 25 °C
- Medium:
- methanol
- Solubility:
- 410 g/L
- Temp.:
- 25 °C
- Medium:
- n-octanol
- Solubility:
- 100 g/L
- Temp.:
- 25 °C
- Medium:
- toluene
- Solubility:
- 100 g/L
- Temp.:
- 25 °C
- Test substance stable:
- yes
- Conclusions:
- The solubility in seven different organic solvents has been determined ranged from 1.3 g/L in hexane to 430 g/L in dichloromethane.
- Executive summary:
The solubility of test substance has been determined in seven organic solvents. As there is no general method available for the determination of the solubility in organic solvents, a procedure similar to that described in CIPAC method MT 157.3 (water solubility: flask method) was used in this study in compliance with GLP. The solubility was found to range 1.3 g/L in hexane to 430 g/L in dichloromethane.
Reference
RESULTS
Table 1 Experimental data
Aceton | Weight of test substance (g) dispersed in 20 mL solvent |
15.39 | |||||||||||
Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
Solubility (g/L) | 353 | 361 | |||||||||||
Average (g/L) | 360 | ||||||||||||
Dichloromethane | Weight of test substance (g) dispersed in 20 mL solvent |
20.96 | |||||||||||
Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
Solubility (g/L) | 443 | 422 | |||||||||||
Average (g/L) | 430 | ||||||||||||
Ethyl acetate | Weight of test substance (g) dispersed in 20 mL solvent |
16.06 | |||||||||||
Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
Solubility (g/L) | 239 | 242 | |||||||||||
Average (g/L) | 240 | ||||||||||||
Hexane | Weight of test substance (g) dispersed in 20 mL solvent |
1.00 |
|||||||||||
Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
Solubility (g/L) | 1.35 | 1.34 | |||||||||||
Average (g/L) | 1.3 | ||||||||||||
Methanol | Weight of test substance (g) dispersed in 20 mL solvent |
20.19 | |||||||||||
Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
Solubility (g/L) | 404 | 412 | |||||||||||
Average (g/L) | 410 | ||||||||||||
Octanol | Weight of test substance (g) dispersed in 20 mL solvent |
7.59 | |||||||||||
Equilibration time at 25 °C | 1 day | 2 days | |||||||||||
Solubility (g/L) | 99 | 100 | |||||||||||
Average (g/L) | 100 |
Description of key information
The test substance can be considered miscible in organic solvents and ranged from 1.3 g/L in hexane to 430 g/L in dichloromethane, CIPAC MT 157.3, Stulz 1998.
Key value for chemical safety assessment
- Solubility in organic solvents at 20°C:
- 1.3 g/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.