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Diss Factsheets
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EC number: 614-482-0 | CAS number: 68439-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
To cover the endpoint skin sensitization of substance C9-11AE (CAS 68439-46-3), a study from a similar substance (C6-12AE; CAS 68439-45-2) was taken for read-across. Read-across is justified because a substantial amount of skin sensitization studies in guinea pigs following either the Magnusson Kligman maximization or the Buehler testing protocol are available to evaluate the skin sensitization potential of alcohol ethoxylates (AE). Although a mild skin sensitization reaction was observed in a study with C7-9AE following the Magnusson Kligman protocol, the weight of evidence clearly supports the assessment that AE should not be considered as skin sensitizers. This is further supported by clinical data that demonstrate the absence skin sensitization responses to AE when tested under the conditions of the HRIPT (HERA, 2009).
The skin sensitizing potential was assessed with C6-12AE (CAS 68439-45-2) in a Guinea Pig Maximization Test according to OECD Guideline 406. In this study ten guinea pigs per sex were induced intradermally with 0.1% test substance (w/v, in corn oil), followed by epicutaneous occlusive induction for 48 hours with 50% test substance (w/v, in corn oil) seven days later. Two weeks later animals were challenged by epicutaneous occlusive exposure for 24 h to 25% test substance (w/v, in corn oil). 24 and 48 hours after patch removal the application site was assessed for signs of local irritation. No dermal reactions were observed in any test animal at any time point.
Migrated from Short description of key information:
GPMT (OECD 406): not sensitising
Justification for selection of skin sensitisation endpoint:
Reliable OECD Guideline study chosen.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
- Migrated from Short description of key information:
No data available.
Justification for classification or non-classification
According to the classification criteria of Directive 67/548/EEC and Regulation (EC) No 1272/2008 the substance does not need to be classified for skin sensitization. No data is available for respiratory sensitization.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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