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EC number: 614-482-0 | CAS number: 68439-46-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Oral (OECD 401), rat: LD50 = 3488 mg/kg bw
Dermal (OECD 402), rat and rabbit: LD50 > 2000 mg/kg bw
Inhalation (OECD 403), rat, 4 h, (limit test): LC50 > 1600mg/m³ (maximum technically attainable concentration)
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 3 488 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 1 600 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 000 mg/kg bw
Additional information
To cover the endpoint acute toxicity of substance C9-11AE (CAS 68439-46-3), studies from similar substances were taken for a weight-of-evidence approach. Read-across is justified because the length of the alkyl chain does not exert any meaningful influence on acute toxicity, whereas the degree of ethoxylation is of more importance. Up to the level of EO = 4, which includes all read-across substances, the toxicity is low (HERA, 2009).
The first acute oral toxicity study with C6-10AE (CAS 112-59-4) was conducted equivalent to OECD Guideline 401. Five Wistar rats were dosed at 900, 1900, 3700, 7400, 15,000 mg/kg bw (males) and 1900, 3700, 7400 mg/kg bw (females), respectively. Mortalities occurred at a dose level of 3700 mg/kg bw and above resulting in a LD50 of 4600 mg/kg bw for males and 3488 mg/kg bw for females, respectively. Clinical signs comprised sluggishness, unsteady gait and a prostrated appearance at all doses. Moreover, necropsy revealed dark red or dark pink lungs in the deceased animals.
The second study addressing acute oral toxicity was conducted with C6-12AE (CAS 68439-45-2) according to OECD Guideline 401. For five males the study was conducted as a limit test with a single dose of 5050 mg/kg bw. The female Sprague-Dawley rats received 4000, 5050 and 5500 mg/kg bw, each dose level consisting of five animals. The LD50 value was determined to be 5130 mg/kg bw for females and greater than 5050 mg/kg bw for males, respectively. Abnormal necropsy findings occurred primarily in the deceased females and pertained to the lungs, liver, and contents of the gastrointestinal tract and bladder.
The final acute oral toxicity study with C10-16AE (CAS 68002-97-1) was as well conducted equivalent to OECD Guideline 401. In this limit test five Sprague-Dawley rats per sex received 5050 mg/kg bw. No mortalities occurred, hence, the LD50 value was set to greater than 5050 mg/kg bw.
For addressing acute dermal toxicity, the same read-across substances as for acute oral toxicity were taken. The first study with C6-10AE (CAS 112-59-4) equivalent to OECD Guideline 402 was carried out on five New Zealand White rabbits per sex and dose. Both sexes were dosed at 900, 1900 and 3700 mg/kg bw under occlusive conditions for 24 hours, with the females receiving an additional dose of 2600 mg/kg bw. Mortalities occurred at a dose level of 1900 mg/kg bw and above, resulting in a LD50 of 2000 mg/kg bw for males and 2216 mg/kg bw for females, respectively. Moreover, necropsy revealed dark red or dark pink lungs in the deceased animals.
The second study regarding acute dermal toxicity was conducted with C6-12AE (CAS 68439-45-2). This limit test was conducted equivalent to OECD Guideline 402, however, only four Wistar rats per sex were used. The dose level of 2000 mg/kg bw was applied occlusive for 24 hours and caused neither treatment-related clinical signs nor mortalities. Hence, the LD50 was determined to be greater than 2000 mg/kg bw.
The third acute dermal toxicity study with C10-16AE (CAS 68002-97-1) was as well a limit test conducted equivalent to OECD Guideline 402. In this limit test five New Zealand White rabbits per sex received 2000 mg/kg bw for a 24 h-occluded exposure. No mortalities occurred, hence, the LD50 value was set to greater then 2000 mg/kg bw.
There are two studies available addressing acute inhalation toxicity, being performed with C6-10AE (CAS 112-59-4) and C10-16AE (CAS 68002-97-1) and equivalent to OECD Guideline 403.
In the first study five Wistar rats per sex were exposed for a period of 6 hours to a vapour of the test substance at the calculated saturated vapour concentration of 100 mg/m³. No mortality or clinical signs occurred during the exposure period. The LC50 was determined to be greater than 100 mg/m³ for exposure to an aerosol of the test substance for 6 hours.
In the second study with C10-16AE (CAS 68002-97-1) five Sprague Dawley rats/sex were exposed for a period of 4 hours to an aerosol of the test substance at a concentration of 1600 mg/m³ (corresponding to 1.6 mg/L), which is the maximum technically attainable concentration of the test substance with a MMAD < 4 µm (limit test). No mortality occurred during the exposure or the 14-day observation period. The animals demonstrated clinical signs of toxicity like slight nasal discharge and lacrimation during exposure as well as slight, red nasal discharge post-exposure. The LC50 was determined to be greater than 1600 mg/m³ for exposure to an aerosol of the test substance for 4 hours.
Justification for selection of acute toxicity – oral endpoint
Study with the lowest definitive dose descriptor was selected.
Justification for selection of acute toxicity – inhalation endpoint
Study with the maximum achievable dose was selected.
Justification for selection of acute toxicity – dermal endpoint
No study chosen due to woe approach.
Justification for classification or non-classification
According to the classification criteria of Directive 67/548/EEC and Regulation (EC) No 1272/2008 the substance does not need to be classified for acute toxicity.
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