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EC number: 469-070-1 | CAS number: 17861-60-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-11-30 to 2006-01-11
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Version / remarks:
- 2004
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- yes
- Details on sampling:
- - Concentrations: 100 mg/L and control
- Sample storage conditions before analysis: stored in refrigerator (4 +/- 4°C) - Vehicle:
- no
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method:
200 mg of the test item were dissolved in 2000 mL test water by stirring for 6 days. During the range-finding test, it was noted that after 96h of stirring, the test item was not visible in the test media. Consequently, no additional filtration was performed after stirring. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Strain/clone: clone 5
- Age at test start: 7 - 23.5h
ACCLIMATION
- Acclimation period: for 7 hours under test conditions - Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 250 mg/L as CaCo3 (reconstituted water)
- Test temperature:
- 19°C
- pH:
- 7.4 - 7.6
- Dissolved oxygen:
- >= 8.2 mg/L
- Nominal and measured concentrations:
- - 100 mg/L (nominal)
- freshly prepared test media (0 h) collected at test start were analysed - Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers of 100 mL volume containing 80 mL test medium
- Renewal rate of test solution (frequency/flow rate): daily
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
OTHER TEST CONDITIONS
- Photoperiod: 16h light: 8h dark
- Light intensity: 202 Lux - Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Details on results:
- The test item had no toxic effect on Daphnia magna at nominal test concentrations of 100 mg/L (loading rate). No daphnids were immobilized after 48 hours of exposure.
The test item concentrations in the freshly prepared samples were below the limit of detection. No further analytics were done. - Validity criteria fulfilled:
- yes
- Conclusions:
- The 48h LC50 of 3-ethylheptamethyltrisiloxane to Daphnia magna was found to be above 100 mg/L (loading rate).
Reference
Table 1: Influence o the test item on the mobility of daphnia magna
Concentration of the test item [mg/L] |
No. of Daphnia tested | No. of immobilized Daphnia after | % of immobilized Daphnia after | ||
24h | 48h | 24h | 48h | ||
Control | 20 | 0 | 0 | 0 | 0 |
100 | 20 | 0 | 0 | 0 | 0 |
Table 2: Dissolved oxygene concentrations and pH-values in the test media
Concentration of the test item [mg/L] |
Start (0h) | 24h old | 24h new | 48h old | ||||
pH | O2 [mg/L] | pH | O2 [mg/L] | pH | O2 [mg/L] | pH | O2 [mg/L] | |
Control | 7.5 | 8.4 | 7.6 | 8.2 | 7.7 | 8.4 | 7.6 | 8.6 |
100 | 7.5 | 8.4 | 7.6 | 8.2 | 7.7 | 8.4 | 7.4 | 8.7 |
Table 3: water temperature in the test media
Concentration of the test item [mg/L] |
Water temperature [°C] | |
Start | End | |
Control | 19 | 19 |
100 | 19 | 19 |
Description of key information
The toxicity of the test item on Daphnia magna was determined in a GLP study according to OECD 202. No adverse effects were observed and the 48h LC50 to Daphnia magna was found to be above 100 mg/L (loading rate).
Key value for chemical safety assessment
Additional information
The toxicity of test item on Daphnia magna was determined in a GLP study according to OECD 202. Individuals of D. magna were exposed to 0 (control), 100 mg/L of the test substance in artificial water. No immobility or mortality of D. magna was observed after 48 h at 100 mg/L. The 48h LC50 to Daphnia magna wa not determinable due to the physico-chemical properties of the test item.
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