2-Cyclopentene-1-carboxylic acid, 5-(dimethylphenylsilyl)-2-(hydroxymethyl)-, (1R,2R)-2-amino-1,3-dihydroxy-1-(4-nitrophenyl)propyl ester, (1R,5S)-

Surface tension

Administrative data

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

3rd May 2005 - 4th May 2005

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: The experimental procedure used complied with that specified in Method A5 of Commission Directive 92/69/EEC, and was carried out in accordance with GLP. The test material was well characterised.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2006

Report date:

2006

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

yes

Remarks:

The surface tension result was not correct using the Harkins-Jordan correction table as the correction is not applicable to the apparatus used. Once calibrated, the balance and the ring assembly used in this test give a direct reading for the surface tens

GLP compliance:

yes

Type of method:

ring method

Test material

Test material information

Constituent 1

Reference substance name:

-

EC Number:

445-910-2

EC Name:

-

Cas Number:

1388152-30-4

Molecular formula:

Hill formula: C24 H32 N2 O7 Si CAS formula: C15 H20 O3 Si . C9 H12 N2 O4

IUPAC Name:

(1R,2R)-1,3-Dihydroxy-1-(4-nitrophenyl)propyl-2-ammonium (1R, 5S)-5-(dimethylphenylsilyl)-2-(hydroxymethyl)cyclopent-2-ene-1-carboxylate

Results and discussion

Surface tension

Surface tension:

54.6 mN/m

Temp.:

20.5 °C

Conc.:

1.02 g/L

Any other information on results incl. tables

The calibration factor for doule-distilled water was generated using 7 surface tension readings at 20.4 -20.6^oC and comparing to the literature values. The Mean calibration Factor was shown to be = 1.002.

Sample solution readings:

Time (mins)	Reading (mN/m)	Temperature (^oC)
57	54.0	20.4
67	54.5	20.4
76	54.5	20.4
83	54.5	20.6
89	54.5	20.4
96	54.5	20.6

Mean reading (last 5) : 54.5 mN/m

Surface tension = reading x calibration factor

= 54.5 x 1.002

= 54.6 mN/m

Temperature : 20.5 +/- 0.5 ^oC

pH of sample solution : 6.2

Applicant's summary and conclusion

Conclusions:

The surface tension of a 1.02 g/L solution of test material has been determined to be 54.6 mN/m at 20.5 degrees celsius. The test material is considered to be a surface-active material.

Executive summary:

Substances haveing a surface tension below 60 mN/m are regarded as being surface-active. Although the test material is surface active, for a test material to be classified as a true surfacant a value of below 40 mN/m should be obtained. This has been deemed to have no significant effect on the adsorption coefficient test ( section 5.4.1).

It is evident from the information obtained in the hydrolysis study (see section 5.1.2) and data relating to pH of the test material in water that negligable hydrolysis of the sample solution occurred during the course of the surface tension study.