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Diss Factsheets
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EC number: 443-870-0 | CAS number: 163520-33-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
Reference
Description of key information
A screening study on biodegradation is not considered to be necessary since higher-tier simulation studies in water/sediment systems as well as in soil are available.
Key value for chemical safety assessment
Additional information
According to the structure and the low solubility in water, the substance is not expected to fulfill the stringent criteria of a ready biodegradation test. However, abiotic degradation via hydrolysis is a relevant pathway for the degradation of the target compound isoxadifen-ethyl (DT50: 2.3 d at 25 °C, pH 7) (OECD 111, EPA Guideline Subdivision N 161-1). Studies have been conducted investigating the transformation of the target compound in different sediment/water systems under aerobic and anaerobic conditions. Under environmental conditions the target substance will degrade with half-lives less than 4 days (DT50 values in sediment/water systems: 0.4 days, and 3.2 days at 12 °C) (US EPA Subdivision N Pesticide Guideline 162-3 and 162-4). Under anaerobic conditions the degradation of the target compound was also fast with a DT50 value of 1.3 days at 12 °C. Three metabolites of the target compound were identified and the degradation of these metabolites was investigated as well. Overall, the metabolites also showed a degradation under aerobic conditions and the formation of CO2 was considerable, thus the metabolites were mineralized. Under anaerobic conditions the mineralization for the metabolites was negligible. But when converting the metabolites to aerobic conditions after 120 days a mineralization to CO2 was determined. There are studies available that demonstrate the same pattern of the target compound and its metabolites for the degradation in soil (US EPA Pesticide Assessment Guidelines, Subdivision N, 162-1, and Society of Environmental Toxicology and Chemistry (SETAC - Europe) Procedures for addressing the environmental fate and ecotoxicology of pesticides; Annex II, Point 7.1.1.1). DT50 values in different soils (4 EU soils and 1 US soil) for the target compound were 0.8 – 2.4 days at 12 °C under aerobic conditions, and 0.042 days under anaerobic conditions. Based on these results, a persistence of the target compound in the aquatic and terrestrial environment is not expected. Hence, an additional readily biodegradation test according to OECD 301 is not reasonable.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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