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EC number: 283-585-7 | CAS number: 84682-23-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Melting point / freezing point
Administrative data
Link to relevant study record(s)
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment. No information on purity of the substance.
- GLP compliance:
- not specified
- Type of method:
- thermal analysis
- Melting / freezing pt.:
- 142 °C
- Conclusions:
- The melting point of the T001159 is 142 deg C.
- Endpoint:
- melting point/freezing point
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 03 September - 15 December 2015
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 102 (Melting point / Melting Range)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.1 (Melting / Freezing Temperature)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7200 (Melting Point / Melting Range)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- differential scanning calorimetry
- Specific details on test material used for the study:
- - Batch n°: M14IB5308
- Analytical purity: 99.6%
- Expiration date: 03 February 2016
- Storage condition: at room temperature - Key result
- Melting / freezing pt.:
- 140.6 °C
- Atm. press.:
- 1 013.25 hPa
- Decomposition:
- yes
- Remarks:
- A black molten residue remained after the preliminary and the first experiment of the main test and a beige molten residue after the second experiment, indicating reaction and/or decomposition.
- Decomp. temp.:
- > 300 °C
- Conclusions:
- The melting temperature of JNJ-16479489-AAA (T001159) was determined to be 140.6°C (413.8K) by using DSC.
Referenceopen allclose all
Preliminary test
From the TGA curve it could be derived that the weight of the sample decreased significantly from 350°C. At 370°C the sample weight has decreased by 25%. After the experiment, a black molten residue remained in the sample container (original colour: off-white). The change of the colour indicated reaction and/or decomposition of the test item.
Main tests
In order to determine the melting more precisely, the DSC curve with a heating rate of 20°C/min was obtained and showed an endothermic peak between 125°C and 175°C. The extrapolated onset temperature of the peak was 140.60°C. The effect was most likely obtained due to melting. An exothermic peak was observed starting at 300°C due to reaction and/or decomposition of the test item. After the experiment, a black molten residue remained. To investigate the melting peak between 125°C and 175°C, a repeated heating cycle was applied. The extrapolated onset temperature of the melting peak was 140.61°C. After the experiment, a beige molten residue remained in the sample container. Since no colour change was observed, it could be concluded that the endothermic effect was due to melting of the test item.
The melting temperature of T001159 was determined as the average melting temperature obtained from Experiment 1 and Experiment 2 and equals 140.6°C (413.8K).
Description of key information
In a GLP study according to OECD guideline 102, EU method A.1 and EPA OPPTS 830.7200 (K1, Reingruber, 2016) the melting point of T001159 was determined to be 140.6°C.
Key value for chemical safety assessment
- Melting / freezing point at 101 325 Pa:
- 140.6 °C
Additional information
A supporting study (Pharmaceutical Science) with insufficient documentation, and therefore assigned as K4, concluded that the melting temperature of T001159 is 142.0°C which is in line with the result of the key study.
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