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EC number: 281-865-3 | CAS number: 84045-63-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- December 06, 2017 - February 02, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- yes
- Remarks:
- refer to 'Any other information on materials and methods' section.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- yes
- Remarks:
- refer to 'Any other information on materials and methods' section.
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- Deviations:
- yes
- Remarks:
- refer to 'Any other information on materials and methods' section.
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: RY-95-001
- Expiration date of the lot/batch: July 1, 2022
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: at room temperature (20 +/- 5°C) in the dark - Key result
- Water solubility:
- 338.3 g/L
- Conc. based on:
- test mat. (dissolved fraction)
- Loading of aqueous phase:
- 625 g/L
- Incubation duration:
- 96 h
- Temp.:
- 20 °C
- pH:
- 6.3
- Conclusions:
- The water solubility of Reactive Yellow 95 (meta) was determined to be 338.3 g/L at 20°C using the flask method.
- Executive summary:
The water solubility of the test item was determined using the shake flask method. The saturation mass concentrations of the test item were determined using HPLC.
The results showed no tendency to increase time-dependent; therefore the study is considered to be valid.
Corresponding to the analyses the water solubility was determined to be 338.3 g/L at 20 °C.
The test item showed extraordinary behaviour. There is only a small window between total solubility and complete absorption of the added liquid.
Two of the six samples seemed to show a super-saturation phenomenon. After the prolonged saturation time at 20°C, additional test item precipitated. These samples were not incorporated in the calculation.
Reference
Preliminary test:
A preliminary test for the water solubility was carried out. The solubility of the test item was estimated by visual solubility testing described in the guidelines. About 100 mg of the test item were filled in a glass-stoppered 10 mL glass tube and increasing volumes of water were added. After each addition the mixture was shaken vigorously for about 10 minutes and afterwards checked for any undissolved parts of the test item.
The solubility of the test item in water was estimated to be about 500 g/L in the preliminary test.
Based on the guideline the shake flask method has to be used for the test performance for substances with solubility > 10 mg/L.
Flask method:
A first approach was conducted with 10 ml of water added to 25 g test item (five-fold concentration derived from the pre-test). After the incubation at 30°C was completed, the test item showed a hard glass-like surface with lots of unwetted test item below. The added water was completely soaked in, no liquid remained. A saturated solution cannot be separated.
The second approach was conducted with 8 ml of water added to 5 g of test item.
After the incubation at 30°C, two of the samples (24h-incubation, Sample 2 and 48h-incubation Sample 1) were completely dissolved; in all of the other samples a saturated solution with remaining visible test item resulted. The saturation at 20°C was prolonged from 24 to 96 hours to ensure total precipitation. Here, all samples showed significant amounts of remaining test item. The solutions were filtered and the concentration of the test item was determined in the clear aqueous phase (saturated solution) separated.
Additionally, a repetition of the filtration and analytical measurement has been conducted because in the two samples completely dissolved after the 30°C-incubation, ongoing precipitation was visible.
Description of key information
The water solubility of Reactive Yellow 95 (meta) was determined to be 338.3 g/L at 20°C using the flask method.
Key value for chemical safety assessment
- Water solubility:
- 338 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the test item was determined using the shake flask method. The saturation mass concentrations of the test item were determined using HPLC.
The results showed no tendency to increase time-dependent; therefore the study is considered to be valid.
Corresponding to the analyses the water solubility was determined to be 338.3 g/L at 20 °C.
The test item showed extraordinary behaviour. There is only a small window between total solubility and complete absorption of the added liquid.
Two of the six samples seemed to show a super-saturation phenomenon. After the prolonged saturation time at 20°C, additional test item precipitated. These samples were not incorporated in the calculation.
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