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EC number: 264-980-3 | CAS number: 64628-44-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- between November 1982 and December 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Triflumuron-chlorophenyl-ring-UL-14C was incubated in sterile buffer solutions (pH 5, 7 and 9, containing 1% acetonitrile) at a concentration of 0.05 ppm and s temperature of 25 °C. Triflumuron was stable at pH- 5 and 7
- GLP compliance:
- no
- Radiolabelling:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Sample Analysis. At intervals of 0, 3, 7, 14 and 30 days, duplicate samples at each pH were radioassayed and analyzed by TLC. TLC was performed on silica gel 60 F-254 (Merck). Each sample was co-chromatographed with non-labeled standards.
The solvent systems employed were benzene/ethyl acetate/acetic acid (50:25:1) and hexane/ethyl acetate/acetic acid (25:25:1).
Radiocarbon zones on each plate were detected by autoradiography on Kodak XAR film. Non-radiolabeled standards were detected by flourescence quenching under ultra-violet light. The radioactive zones were isolated and radioassayed in a liquid scintillation spectrometer (Packard Instrument Co., Model No. 406). - Buffers:
- The pH 5 and 7 buffers were prepared from distilled water using potassium biphidsphatem (KH2P04) and disodium phosphate (Na2HP04-7H20)2. The pH 9 buffer was prepared using boric acid (H3B03)-potassium chloride (KCl) and sodium hydroxide (NaOH)3. Final pH of the solutions were checked using an Orion Research, Model 201, pH meter.The pH of the buffers remained constant throughout the entire study at 5.2, 7.1 and 9.2, respectively.
- Duration:
- 30 d
- pH:
- 5
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.05 other: ppm
- Duration:
- 30 d
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.05 other: ppm
- Duration:
- 30 d
- pH:
- 9
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.05 other: ppm
- Transformation products:
- yes
- No.:
- #1
- Details on hydrolysis and appearance of transformation product(s):
- The major degradation product at pH 9 was 2-chlorobenzoic acid as determined by co-chromatography with an authentic standard in two TLC systems and by HPLC, The minor amount of 2-chlorobenzamide found in all buffer solutions was apparently a contaminant in the original Triflumuron standard.
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- 465 d
- Type:
- (pseudo-)first order (= half-life)
- Remarks on result:
- other: slight degradation
- Key result
- pH:
- 9
- Temp.:
- 25 °C
- DT50:
- 57 d
- Type:
- (pseudo-)first order (= half-life)
- Details on results:
- The concentration after sonication for 30 minutes and ultracentrifugation for 2 hours appeared to plateau at 0.08 ppm. The pH of the buffers remained constant throughout the entire study at 5.2, 7.1 and 9.2, respectively.
Triflumuron was stable at pH 5 with no degradation detected throughout 30 days. Only slight degradation of the compound was detected after 30 days at pH 7 where an extrapolated half-life was calculated to be 465 days. For practical purposes, the compound could be considered stable at neutral pH conditions. Triflumuron in pH 9 buffered solutions exhibited a half-life of 57 days. Calculation of half-lives was based on first order kinetics using a straight line plot of log concentration versus time according to a least squares fit of the data. The major degradation product at pH 9 was 2-chlorobenzoic acid as determined by co-chromatography with an authentic standard in two TLC systems and by HPLC, The minor amount of 2-chlorobenzamide found in all buffer solutions was apparently a contaminant in the original Triflumuron standard. - Validity criteria fulfilled:
- yes
- Conclusions:
- This study investigated the hydrolysis of chlorophenyl-labelled triflumuron in sterile buffer solutions (pH 5, 7 and 9; 0.05 ppm; 25 °C) over a 30-day period. Triflumuron was stable at pH 5 and 7; the half-life at pH 9 was 57 days. No volatile degradation products were found. The primary degradation product was 2-chlorobenzoic acid (CBA).
- Executive summary:
Triflumuron-chlorophenyl-ring-UL-14C was incubated in sterile buffer solutions (pH 5, 7 and 9, containing 1% acetonitrile) at a concentration of 0.05 ppm and s temperature of 25°C. Triflumuron was stable at pH- 5 and 7. the half-life at pH 9 was 57 days. No volatile degradation products were found. The primary degradation product in solution was 2-chlbrobenzoic acid.
Reference
Description of key information
This study investigated the hydrolysis of chlorophenyl-labelled triflumuron in sterile buffer solutions (pH 5, 7 and 9; 0.05 ppm; 25 °C) over a 30-day period. Triflumuron was stable at pH 5 and 7; the half-life was estimated to be 465 days at pH 7 and at pH 9 was 57 days. No volatile degradation products were found. The primary degradation product was 2-chlorobenzoic acid (CBA).
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 465 d
- at the temperature of:
- 25 °C
Additional information
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