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EC number: 260-257-1 | CAS number: 56554-53-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: long-term
- Data waiving:
- other justification
- Justification for data waiving:
- other:
Reference
Description of key information
Key value for chemical safety assessment
Additional information
The chemical safety assessment according to Annex I of Regulation (EC) No. 1907/2006 does not indicate the need to investigate further the effects on sediment organisms. Experimental data on the toxicity of propane-1,2,3-triyl 3,5,5-trimethylhexanoate (CAS No. 56554-53-1) to sediment organisms are not available. Acute and chronic toxicity test on aquatic organisms show that the substance is not toxic to aquatic organisms up to the limit of water solubility. Thus, toxicity to sediment organisms is not expected to be of concern.
Intrinsic properties of the substance indicate low concern for sediment organisms. Propane-1,2,3-triyl 3,5,5-trimethylhexanoate (CAS No. 56554-53-1) reached 60% biodegradation after 28 days. Therefore, extensive biodegradation in biological Sewage Treatment Plants (STPs) is expected. After passing through conventional STPs, only low concentrations of this substance are likely to be (if at all) released into the environment.
Furthermore, the substance exhibits a log Koc value > 5 and is poorly soluble in water (< 0.05 mg/L). The Guidance on information requirements and chemical safety assessment, Chapter R7.b (ECHA, 2012) states that once insoluble chemicals enter a standard STP, they will be extensively removed in the primary settling tank and fat trap and thus, only limited amounts will get in contact with activated sludge organisms. Nevertheless, once this contact takes place, these substances are expected to be removed from the water column to a significant degree by adsorption to sewage sludge (Guidance on information requirements and chemical safety assessment, Chapter R.7a, (ECHA, 2012)) and the rest will be extensively biodegraded. Thus, discharged concentrations of these substances into the aqueous/sediment compartment are likely to be negligible. Considering this, the availability of propane-1,2,3-triyl 3,5,5-trimethylhexanoate (CAS No. 56554-53-1) in the sediment environment is expected to be very low, which reduces the probability of sediment organisms exposure.
Furthermore, according to the Guidance on information requirements and chemical safety assessment, Chapter R7.c (ECHA, 2012), the potential for bioaccumulation can be estimated from the log Kow value of the substance as a screening approach. Generally, at log Kow values > 6 a decrease in BCF values is observed, probably caused by the reduced uptake with the expected increasing molecular size of such substances. Even though experimental data evaluating bioaccumulation for substances with log Kow > 10 (such as propane-1,2,3-triyl 3,5,5-trimethylhexanoate (CAS No. 56554-53-1)) is not known, these substances are expected to have BCF values < 2000 L/kg (criterion used to consider a substance Bioaccumulative)(Guidance on information requirements and chemical safety assessment, Chapter 11 (ECHA, 2012). Based on the above information,no potential for bioaccumulation in sediment organisms is to be expected for propane-1,2,3-triyl 3,5,5-trimethylhexanoate.
Available acute and chronic aquatic toxicity tests on fish and aquatic invertebrates determined no adverse effects in the range of the water solubility of the substance. The acute toxicity of the substance was tested in a short-term study on Zebra fish (Danio rerio). Mortality or symptoms of intoxication were not observed (LC50 (96 h) >100% v/v (nominal)). A comparable result was reported by a chronic toxicity test on Daphnia magna. The study focused on the mortality and reproduction of the test animals and determined no toxic effects up to the limit of water solubility (NOEC (21 d): 100% v/v (nominal)).
Based on the currently available information, sediment toxicity is not expected for propane-1,2,3-triyl 3,5,5-trimethylhexanoate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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