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EC number: 255-980-4 | CAS number: 42872-29-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Experimental starting: 2008-10-23 - Experimental completion: 2009-02-13
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study according to international guideline
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 B (Ready Biodegradability: CO2 Evolution Test)
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-(1-cyanoethyl)benzoyl chloride
- EC Number:
- 255-980-4
- EC Name:
- 3-(1-cyanoethyl)benzoyl chloride
- Cas Number:
- 42872-29-7
- Molecular formula:
- C10H8ClNO
- IUPAC Name:
- 3-(1-cyanoethyl)benzoyl chloride
- Details on test material:
- Test item: Ketoprofen / CFPPN
Batch number: F-PPR-080059
CAS RN: 42872-29-7
Chemical name: 3-(1-Cyanoethyl)benzoyl chloride
Content: 95.0%
Carbon content in the vessel : 11.8 mg C/L
Appearance: Brown liquid
Sum formula: C10H8ClNO
Molecular weight: 193.63 g/mol
Water solubility: Hydrolyses at 20 °C
TOC: 58.93% (calculated)
Expiry date: 2009-08-12
Recommended storage: Refrigerator, 7 ± 2 °C, protected from moisture and light
Storage at test facility: 6 ± 2 oc, protected from moisture and Iight
Retention of test item: At least 1 g has been retained.
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, non-adapted
- Details on inoculum:
- Source: Municipal sewage treatment plant, D-31137 Hildesheim
Pretreatment: The activated sludge was washed twice with autoclaved tap water.
After the second washing the settled sludge was filled up with mineral salts medium and was maintained in an aerobic condition by aeration for four hours. Thereafter the sludge was homogenized with a blender. The supernatant was decanted and maintained in an aerobic condition by aeration with C02 free air for 2 days. 10 ml/L were used to initiate inoculation.
Colony forming units in the test vesseI: 10^7 - 10^8 CFU/L - Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 20 mg/L
- Based on:
- test mat.
- Initial conc.:
- 0.589 other: C/mg
- Based on:
- other: TOC
- Initial conc.:
- 2.17 other: mg CO2/mg
- Based on:
- other: ThCO2
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
- TOXICITY CONTROL
Test item and reference item in test concentration
Replicates: Single
INOCULUM CONTROL
Test medium without test and reference item
Replicates: Duplicates
PROCEDURE
Duration: 28 d
Application: Once at test start
Test vessels: 5000 ml, brown glass
Volume of the test medium: 3000 ml
Test medium: Mineral salts medium ace. to OECD 301 B I C02 Evolution Test
Test temperature: 21.0- 23.5 °C
Dispersion treatment: Continuous stirring
Aeration: 30- 100 ml/min
Photoperiod: Low light conditions
Reference substance
- Reference substance:
- benzoic acid, sodium salt
Results and discussion
% Degradationopen allclose all
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 10
- Sampling time:
- 18 d
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 25
- Sampling time:
- 28 d
- Details on results:
- Toxicity control: biodegradation rate of 56 % was determined within 14 days and it came to 73% after 28 days. The biodegradation of the reference item was not inhibited by the test item.
The 10 % level (beginning of biodegradation) of the test item was reached after a long lasting adaptation phase of 18 days. In the further course, the biodegradation increased slowly and on day 28 a mean biodegradation rate of 25% was reached.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- not inherently biodegradable
- Conclusions:
- The test item must be regarded as not readily biodegradable in the 10-d-window and after 28 days.
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