Registration Dossier
Registration Dossier
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EC number: 251-598-7 | CAS number: 33619-92-0
Dissociation constant
Administrative data
Link to relevant study record(s)
- Endpoint:
- dissociation constant
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12-06-2012 - 22-08-2012
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 112 (Dissociation Constants in Water)
- Principles of method if other than guideline:
- The OECD Guideline 112 covers pure substances.
The sample tested contains 50% of the substance in solution, including different impurities and also NaOH as a stabilizer. - GLP compliance:
- no
- Dissociating properties:
- yes
- No.:
- #1
- pKa:
- >= 7.62 - <= 7.64
- Temp.:
- 19.5 °C
- Remarks on result:
- other:
- Remarks:
- Measured on sample including impurities
- Conclusions:
- The dissociation constant pKa at 19.5ºC is 7.63 ± 0.010
The sample tested contains different impurities and also NaOH as a stabilizer, this could have an impact on the test result.
Reference
The pKa was calculated for 10 measured point at the half equivalence point of the titration curve.
A threefold determination was performed.
Description of key information
The dissociation constant pKa at 19.5ºC is 7.63 ± 0.010
The sample tested contains different impurities and also NaOH as a stabilizer, this could have an impact on the test result.
Key value for chemical safety assessment
- pKa at 20°C:
- 7.63
Additional information
Dehydrated sample of SBP1-Na
(SBP1-Na produced by adding aqueous NaOH to SBP-1)
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