Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-280-0 | CAS number: 13718-59-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to soil macroorganisms except arthropods: long-term
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Standard guideline followed (OECD 220, 2003), well performed and well documented study.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 220 (Enchytraeid Reproduction Test)
- GLP compliance:
- not specified
- Analytical monitoring:
- yes
- Details on sampling:
- Soils were sampled from each concentration 24-48 hours after spiking and stored at 4°C until Se analyses.
- Vehicle:
- no
- Details on preparation and application of test substrate:
- see test conditions
- Test organisms (species):
- Enchytraeus albidus
- Animal group:
- annelids
- Details on test organisms:
- TEST ORGANISM
- Common name: Pot worm
- Source: originated from the E. albidus stock cultures of the Department of Zoology and Ecology, Szent István University
- Age at test initiation (mean and range, SD): adult worms with fully developed clitellum and visible eggs - Study type:
- laboratory study
- Substrate type:
- natural soil
- Limit test:
- no
- Total exposure duration:
- 6 wk
- Test temperature:
- 18 degree C
- pH:
- 7.1
- Moisture:
- soil was watered to 55% WHC
- Details on test conditions:
- TEST SYSTEM
- Test container (material, size): 150 mL containers covered by their own cups and randomly placed in a thermostat
- Amount of soil or substrate: 20 g oven dry soil
- No. of organisms per container (treatment): 10
- No. of replicates per treatment group: 5
- No. of replicates per control: 5
SOURCE AND PROPERTIES OF SUBSTRATE (if soil)
- Geographic location: Nagyhörcsök, Hungary (soil from control plots of the experimental field of the Research Institute for Soil Science and Agricultural Chemistry (RISSAC) of the Hungarian Academy of Sciences)
- Soil texture (if natural soil): calcareous loamy chernozem with medium to deep humus layer formed on loess
- % sand: no data
- % silt: no data
- % clay: 20%
- Organic carbon (%): 3.1% organic matter
- eCEC: 40 meq/100g
- background concentration: 0.23 and 0.77 mg Se/kg dw for reproduction and mortality assay, respectively
OTHER TEST CONDITIONS
- Photoperiod: the tests were performed in total darkness
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): mortality and reproduction - Nominal and measured concentrations:
- Measured: 0.77-6.21-12.8-24.8-42.6-76.6-132.0 mg Se/kg dw (mortality tests)
Measured: 0.23-1.20-2.35-5.08-9.975-20.55-43.95 mg Se/kg dw (reproduction tests) - Duration:
- 6 wk
- Dose descriptor:
- NOEC
- Effect conc.:
- 2.12 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Se (added concentration)
- Basis for effect:
- reproduction
- Remarks on result:
- other: total concentration: 2.35 mg Se/kg
- Duration:
- 6 wk
- Dose descriptor:
- EC10
- Effect conc.:
- 2.57 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Se (added concentration)
- Basis for effect:
- reproduction
- Remarks on result:
- other: total concentration: 2.8 mg Se/kg (95% CL: 1.61-3.74)
- Duration:
- 6 wk
- Dose descriptor:
- EC50
- Effect conc.:
- 7.07 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Se (added concentration)
- Basis for effect:
- reproduction
- Remarks on result:
- other: total concentration: 7.3 mg Se/kg (95% CL: 6.2-8.5)
- Duration:
- 6 wk
- Dose descriptor:
- NOEC
- Effect conc.:
- 5.44 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Se (added concentration)
- Basis for effect:
- mortality
- Remarks on result:
- other: total concentration: 6.21 mg Se/kg
- Duration:
- 6 wk
- Dose descriptor:
- LC10
- Effect conc.:
- 6.53 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Se (added concentration)
- Basis for effect:
- mortality
- Remarks on result:
- other: total concentration: 7.3 mg Se/kg (95% CL: 5.07-6.21)
- Duration:
- 6 wk
- Dose descriptor:
- LC50
- Effect conc.:
- 21.73 mg/kg soil dw
- Nominal / measured:
- meas. (not specified)
- Conc. based on:
- element
- Remarks:
- Se (added concentration)
- Basis for effect:
- mortality
- Remarks on result:
- other: total concentration: 22.5 mg Se/kg (95% CL: 19.6-25.7)
- Reported statistics and error estimates:
- The NOEC for reproduction and mortality was calculated by the t test.
Probit analysis was based on linear maximum likelihood regression. - Conclusions:
- This Klimisch 1 study was performed according to OECD guideline 220. It was a well performed and well documented study that evaluated the effects of sodium selenite on reproduction and mortality of adult pot worms (Enchytraeus albidus). The 6-week NOEC for reproduction was 2.35 mg Se/kg dw and for mortality was 6.21 mg Se/kg dw.
Reference
Description of key information
The lowest reliable EC10 for Na2SeO3 is 2.57 mg Se/kg soil (added concentration) for reproduction of Enchytraeus albidus after 6 weeks exposure, according to the OECD 220 guideline (Somogyi et al., 2007; Klimisch 1).
Key value for chemical safety assessment
- Long-term EC10, LC10 or NOEC for soil macroorganisms:
- 2.57 mg/kg soil dw
Additional information
Reliable results are available for the toxicity of Na2SeO3 and Na2SeO4 to soil macro-organisms except arthropods. Somogyi et al. (2007) studied the effect of both Na2SeO3 and Na2SeO4 on mortality and reproduction of the potworm Enchytraeus albidus according to the OECD 220 guideline. There was a significant difference in toxicity between selenite and selenate, with selenate showing significantly higher toxicity. This is consistent with data for plants and the lower adsorption of selenate in soil compared to selenite. Therefore, only the available reliable results for selenite are taken into account for the hazard assessment of tetravalent inorganic Se substances.
Reliable chronic toxicity data for sodium selenite are only availble for Enchytraeus albidus and vary between 2.6 and 8.4 mg Se/kg soil (lowest value reported for reproduction after 6 weeks exposure, Somogyi et al., 2007).
In addition, reliable chronic NOEC or EC10 values for toxicity of sodium selenate are available for 3 organisms: Eisenia fetida, Enchytraeus crypticus and Enchytraeus albidus, and vary between 1.7 and 3.4 mg Se/kg soil. The lowest reported reliable NOEC for Na2SeO4was 1.7 mg Se/kg soil (calculated as EC20/2) for reproduction of Eisenia fetida after 13 weeks exposure (Checkai et al., 2004).
All results are based on nominal added or background corrected measured Se concentrations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)