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EC number: 236-885-7 | CAS number: 13532-94-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
2-Butoxyethyl methacrylate can be regarded as having a limited capacity to induce an adverse skin sensitising reaction according to an expert assessment that incorporated Quantitative Structure-Activity Relationship (QSAR) prediction.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation, other
- Type of information:
- other: Expert assessment
- Adequacy of study:
- key study
- Study period:
- April 04, 2018
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: An assessment was undertaken based on a Quantitative Structure-Activity Relationship (QSAR) prediction obtained for the substance in the OECD QSAR Toolbox.
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- To determine the capacity of 2-butoxyethyl methacrylate to induce skin sensitisation, a prediction was obtained for the registered substance in the OECD Quantitative Structure-Activity Relationship (QSAR) Toolbox.
- GLP compliance:
- no
- Type of study:
- other: Expert assessment
- Key result
- Parameter:
- other: Skin sensitisation
- Vehicle controls validity:
- not applicable
- Negative controls validity:
- not applicable
- Positive controls validity:
- not applicable
- Remarks on result:
- no indication of skin sensitisation
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- 2-Butoxyethyl methacrylate was determined not to be a skin sensitiser according to an expert assessment based on Quantitative Structure-Activity Relationships (QSAR). Classification as a skin sensitiser is subsequently not required (CLP Regulation (EC) No 1907/2006).
- Executive summary:
To determine whether 2-butoxyethyl methacrylate has the capacity to induce skin sensitisation, as assessment was undertaken as part of a weight of evidence. Available experimental date was not available in the literature for 2-butoxyethyl methacrylate and, therefore, a Quantitative Structure-Activity Relationship (QSAR) prediction was obtained in the OECD QSAR Toolbox. Based on substances belonging the chemical categories ‘Acrylates/Methacrylates’ and ‘Esters’ (US-EPA New Chemical Categories) and ‘Monoethylene glycol ethers’ (OECD HPV Chemical Categories), all attained predictions were negative and statistically significant (p < 0.05). This result is supportive of 2-butoxyethyl methacrylate having a limited capacity to induce skin sensitisation. Classification under CLP Regulation (EC) No 1907/2006 as a skin sensitiser has been concluded not to be required.
Reference
2-Butoxyethyl methacrylate is not expected to induce skin sensitisation.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
Justification for classification or non-classification
Classification under CLP Regulation (EC) No 1907/2006 as a skin sensitiser has been concluded not to be required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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