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EC number: 230-053-7 | CAS number: 6928-85-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: screening tests
- Type of information:
- (Q)SAR
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- results derived from a valid (Q)SAR model and falling into its applicability domain, with limited documentation / justification
- Justification for type of information:
- The supporting QMRF report has been attached.
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 301 C (Ready Biodegradability: Modified MITI Test (I))
- Principles of method if other than guideline:
- Prediction was done using OECD QSAR tool box v.3.3
- GLP compliance:
- not specified
- Specific details on test material used for the study:
- - Name of test material: 4-methylpiperazin-1-amine
- Molecular formula : C5H13N3
- Molecular weight : 115.179 g/mol
- Smiles notation : N1(CCN(CC1)C)N
- Substance type:Organic
- Physical state:Liquid - Oxygen conditions:
- aerobic
- Inoculum or test system:
- other: Microorganisms
- Duration of test (contact time):
- 28 d
- Parameter followed for biodegradation estimation:
- other: BOD
- Key result
- Parameter:
- other: BOD
- Value:
- 0.5
- Sampling time:
- 28 d
- Remarks on result:
- other: other details not available
- Details on results:
- The test chemical 4-methylpiperazin-1-amine showed 0.5% biodegradability by considering BOD as parameter in 28 days.
- Validity criteria fulfilled:
- not specified
- Interpretation of results:
- not readily biodegradable
- Conclusions:
- The test chemical 4-methylpiperazin-1-amine showed 0.5 % biodegradation in 28 days by considering BOD as parameter and microorganisms as inoculum therefore it is concluded that this test chemical 4-methylpiperazin-1-amine is not readily biodegradable.
- Executive summary:
Biodegradability of test chemical 4-methylpiperazin-1-amine is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor.The test chemical 4-methylpiperazin-1-amine showed 0.5 % biodegradation in 28 days by considering BOD as parameter and microorganisms as inoculum therefore it is concluded that this test chemical 4-methylpiperazin-1-amine is not readily biodegradable.
Reference
The
prediction was based on dataset comprised from the following
descriptors: BOD
Estimation method: Takes average value from the 6 nearest neighbours
Domain logical expression:Result: In Domain
(((((("a"
or "b" or "c" )
and "d" )
and "e" )
and "f" )
and "g" )
and ("h"
and "i" )
)
Domain
logical expression index: "a"
Referential
boundary: The
target chemical should be classified as Aliphatic Amines by US-EPA New
Chemical Categories
Domain
logical expression index: "b"
Referential
boundary: The
target chemical should be classified as Radical OR Radical >> Radical
mechanism via ROS formation (indirect) OR Radical >> Radical mechanism
via ROS formation (indirect) >> Hydrazine Derivatives by DNA binding by
OASIS v.1.3 ONLY
Domain
logical expression index: "c"
Referential
boundary: The
target chemical should be classified as SN1 OR SN1 >> Iminium Ion
Formation OR SN1 >> Iminium Ion Formation >> Aliphatic tertiary amines
by DNA binding by OECD ONLY
Domain
logical expression index: "d"
Referential
boundary: The
target chemical should be classified as days - weeks by Biodeg primary
(Biowin 4) ONLY
Domain
logical expression index: "e"
Referential
boundary: The
target chemical should be classified as Does NOT Biodegrade Fast by
Biodeg probability (Biowin 1) ONLY
Domain
logical expression index: "f"
Referential
boundary: The
target chemical should be classified as weeks - months by Biodeg
ultimate (Biowin 3) ONLY
Domain
logical expression index: "g"
Referential
boundary: The
target chemical should be classified as SN1 AND SN1 >> Iminium Ion
Formation AND SN1 >> Iminium Ion Formation >> Aliphatic tertiary amines
by DNA binding by OECD ONLY
Domain
logical expression index: "h"
Parametric
boundary:The
target chemical should have a value of Molecular weight which is >= 99.1
Da
Domain
logical expression index: "i"
Parametric
boundary:The
target chemical should have a value of Molecular weight which is <= 172
Da
Description of key information
Biodegradation in water
Biodegradability of test chemical 4-methylpiperazin-1-amine is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor.The test chemical 4-methylpiperazin-1-amine showed 0.5 % biodegradation in 28 days by considering BOD as parameter and microorganisms as inoculum therefore it is concluded that this test chemical 4-methylpiperazin-1-amine is not readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
Biodegradation in water:
Various biodegradations studies were performed for test substance 4-Methylpiperazin-1-amine (CAS No: 6928-85-4) to determine its percentage biodegradability in water which are summarized below by using available data for target substance, data from prediction model based estimation and data from its read across substance.
Biodegradability of test chemical 4-methylpiperazin-1-amine is predicted using OECD QSAR tool box v.3.3 using log Kow as primary descriptor.The test chemical 4-methylpiperazin-1-amine showed 0.5 % biodegradation in 28 days by considering BOD as parameter and microorganisms as inoculum therefore it is concluded that this test chemical 4-methylpiperazin-1-amine is not readily biodegradable.
Another prediction done by using Estimation Programs Interface Suite (EPI suite, 2017). The biodegradation potential of the test 4-Methylpiperazin-1-amine (CAS No: 6928-85-4) in the presence of mixed populations of environmental microorganisms. The biodegradability of the substance 4-Methylpiperazin-1-amine (CAS No: 6928-85-4) was calculated using seven different models such as Linear Model, Non-Linear Model, Ultimate Biodegradation Timeframe, Primary Biodegradation Timeframe, MITI Linear Model, MITI Non-Linear Model and Anaerobic Model (called as Biowin 1-7, respectively) of the BIOWIN v4.10 software. The results indicate that chemical 4-Methylpiperazin-1-amine (CAS No: 6928-85-4) is expected to be not readily biodegradable.
In a supporting weight of evidence study of read across substance piperazine, biodegradation study was conducted by Japan chemicals collaborative knowledge database (J-check, 2017) for 14 days for evaluating the percentage biodegradability of read across substance Piperazine (CAS No: 110-85-0). In this test, concentration of inoculum i.e, sludge used was 30 mg/l and initial concentration of read cross substance used in the study was100 mg/l. The percentage degradation of read cross substance obtained was 1.4% by BOD, 1% by TOC removal and 2.8% by GC in 14 days. Thus, the substance Piperazine (CAS No: 110-85-0) is expected to be not readily biodegradable in water.
In another weight of evidence study for read across chemical 1,4 -diaminobenzene conducted by Japan chemicals collaborative knowledge database (J-check), 2017 biodegradation test was carried out for read across substance 1, 4-diaminobenzene (CAS No: 106-50-3) to determine its percentage biodegradability using an activated sludge inoculum. The test system contained 100 mg/L of read across chemical and activated sludge inoculum at 30 mg/L and by using BOD as parameter to determine the percentage biodegradation.The read across substance 1, 4-diaminobenzene (CAS No: 106-50-3) showed 5% biodegradation by considering BOD parameter in 28 days. Thus, the read cross substance 1, 4-diaminobenzene (CAS No: 106-50-3) can be considered as not readily biodegradable.
On the basis of available data for target substance 4-Methylpiperazin-1-amine (CAS No: 6928-85-4) ( from OECD QSAR tool box v.3.3 ans EPI suite 2017) and for its read across substances Piperazine(CAS No: 110-85-0) and 1,4-diaminobenzene (CAS No: 106-50-3) ( from j check 2017) it can be concluded that the test substance 4-Methylpiperazin-1-amine (CAS No: 6928-85-4) can be expected to be not readily biodegradable in water.
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