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EC number: 227-367-1 | CAS number: 5807-14-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
SKIN IRRITATION/CORROSION
Corrosive, New Zealand White rabbit, OECD 404 and EU Method B.4
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (corrosive)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
A study was performed to assess the irritancy potential of the test material to the skin of the New Zealand White rabbit in accordance with the standardised guidelines OECD 404 and EU Method B.4. The study was awarded a reliability score of 1 in accordance with the criteria set forth by Klimisch et al. (1997).
Available information indicated that the test material had the potential to produce severe irritation/corrosion; to confirm this initial assessment, an ex vivo pre-screen test, the Transcutaneous Electrical Resistance (TER) Assay, was performed. The results of the pre-screen test indicated that the test material was considered not to be corrosive to the skin and the in vivo study was performed.
0.5 g of the test material, moistened with distilled water, was applied under a gauze patch to the clipped skin of one rabbit. The patch was removed 3 minutes after application and any residual test material removed with cotton wool soaked in distilled water. The reaction of the skin was evaluated 1 hour and 24 hours following the removal of the patch.
The test material produced reactions indicative of dermal corrosion. The reactions included light green coloured dermal necrosis, surrounded by dermal haemorrhage, and a sunken, hardened dark brown/black coloured scab. The animal was killed for humane reasons immediately after the 24 hour observation, due to the irreversible effects.
Due to the corrosive reactions following an exposure period of 3 minutes, the 1 and 4 hour exposure periods were not investigated.
Under the conditions of this study, the test material was corrosive to rabbit skin.
On the basis of this result, the test material was also assumed to cause serious damage to the eye and no in vivo testing was carried out.
Justification for classification or non-classification
In accordance with the criteria for classification as defined in Annex I, Regulation (EC) No. 1272/2008, the substance requires classification with respect to skin corrosion and serious eye damage. The test material requires classification as skin corrosive Category 1A (H314 Causes severe skin burns and eye damage) and as eye damage Category 1 (H318 Causes serious eye damage).
In accordance with the criteria for classification as defined in Annex VI, Directive 67/548/EEC (DSD), the substance requires classification with respect to skin and eye damage as R35 causes severe burns (C).
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