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Diss Factsheets
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EC number: 224-736-9 | CAS number: 4468-02-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2001
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
The read-across hypothesis is instantaneous dissociation of zinc gluconate into zinc cations (Zn2+) and gluconate anions in aqueous media (environmental compartments and body fluids). Thus, for endpoints where no zinc gluconate data exist, the assessment can be based on available data of dissociable zinc compounds and gluconate derivatives.
Considering that the substance is thus composed of two ions: zinc cations (Zn2+) and gluconate anion.
Zinc ion is inorganic, consequently according to the § 9.2.1.1. in column 2, annex VII of REACH the study does not need to be conducted. Only the organic part (gluconate) is relevant.
The experimental study is cited in the OECD SIDS report on gluconic acid and its derivatives. Consequently, the study is considered as reliable since it is from a collection of data made by OECD, an institute well-known for the quality of its bibliographic reviews.
The experimental study was conducted on Sodium D-gluconate as test material. As zinc gluconate, sodium gluconate dissociates in aqueous media into metal ion (sodium) and gluconate anion. Consequently, for the two substances, the same dissociated organic part is present in water media. In the OECD SIDS, the same read-across approach was used to extrapolate this result to other gluconic acid derivatives.
Taking into account the approach provided, the present read-across is considered relevant and reliable.
Ref :
SIDS Initial Assessment Report for SIAM 18: GLUCONIC ACID AND DERIVATIVES 2004.
Orignial experimental study cited: Hydrotox GmbH (2001). Closed bottle test of sodium D-gluconate, according to 92/69/EWG, C.4-E. Study Number 01/1004. Prepared by Hydrotox GmbH, 2001. Unpublished, sponsored by Jungbunzlauer S.A., Marckolsheim, France. - Reason / purpose for cross-reference:
- read-across source
- Test performance:
- No unusual observations during test.
- Key result
- Parameter:
- % degradation (O2 consumption)
- Value:
- 61
- Sampling time:
- 3 d
- Remarks on result:
- other: meets 10-day window
- Parameter:
- % degradation (O2 consumption)
- Value:
- 89
- Sampling time:
- 28 d
- Remarks on result:
- other: maximum degradation
- Results with reference substance:
- degradation of 67% after 3 days
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- The tested substance Sodium D-gluconate is readily biodegradable under tested condition.
- Executive summary:
Sodium D-gluconate biodegradation ws investigated under Closed Bottle Test. The tested substance Sodium D-gluconate is readily biodegradable under tested condition. This test is cited and used in the SIDS report on gluconic acid and its derivatives.
Reference
Description of key information
The organic part is assess by read-across approach (two compounds with the same dissocitate organic part in media water). The substance is considered readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
- Type of water:
- freshwater
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.