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Registration Dossier
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Diss Factsheets
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EC number: 212-791-1 | CAS number: 870-08-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 305 (Bioaccumulation in Fish: Aqueous and Dietary Exposure) -III: Dietary Exposure Bioaccumulation Fish Test
- Deviations:
- no
- GLP compliance:
- yes
- Radiolabelling:
- no
- Vehicle:
- no
- Test organisms (species):
- other: Rainbow trout, fish
- Route of exposure:
- feed
- Justification for method:
- dietary exposure method used for following reason: solubility of test substance analytical not to detect (LQ0 ~ 5ng/L)
- Test type:
- flow-through
- Water / sediment media type:
- natural water: freshwater
- Total exposure / uptake duration:
- 14 d
- Total depuration duration:
- 14 d
- Reference substance (positive control):
- not required
- Lipid content:
- 4.28 %
- Time point:
- start of exposure
- Lipid content:
- 4.79 %
- Time point:
- end of exposure
- Lipid content:
- 6.76 %
- Time point:
- other: end of DEPURATION PHASE
- Key result
- Conc. / dose:
- 208 µg/g food
- Temp.:
- 15 °C
- pH:
- 6.8
- Type:
- BMF
- Value:
- 0.003 dimensionless
- Basis:
- whole body w.w.
- Calculation basis:
- kinetic
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- steady state not reached
- Key result
- Conc. / dose:
- 208 µg/g food
- Temp.:
- 15 °C
- pH:
- 6.8
- Type:
- BMF
- Value:
- 0.006 dimensionless
- Basis:
- normalised lipid fraction
- Calculation basis:
- kinetic, corrected for growth
- Remarks on result:
- not determinable because of methodological limitations
- Remarks:
- steady state not reached
- Key result
- Elimination:
- yes
- Parameter:
- DT90
- Depuration time (DT):
- 8.47 d
- Key result
- Rate constant:
- growth rate constant (d-1)
- Value:
- 0.014
- Key result
- Rate constant:
- overall depuration rate constant (d-1)
- Value:
- 0.272
- Key result
- Rate constant:
- growth-corrected depuration rate constant (d-1)
- Value:
- 0.258
- Validity criteria fulfilled:
- yes
- Conclusions:
- The kinetic biomagnification factor BMFK was = 0.00261. The lipid and growth normalized biomagnification factor BMFKgL was 0.00637.
Reference
Description of key information
.
Key value for chemical safety assessment
- BCF (aquatic species):
- 0.5 dimensionless
- BMF in fish (dimensionless):
- 0.006
Additional information
There are only (Q)SAR data available for this endpoint. Tge 8Q)SAR data are supoirted by environmental measurements of MSCA. There was no dioctlytin detected nor in limnic or marine biiota neither in human.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.