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EC number: 212-506-0 | CAS number: 822-89-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
- Endpoint:
- adsorption / desorption: screening
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2002-05-21 to 2002-05-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 002
- Report date:
- 2002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- other: HPLC column
Test material
- Reference substance name:
- Hydroxyl-2-pyridone
- EC Number:
- 212-506-0
- EC Name:
- Hydroxyl-2-pyridone
- Cas Number:
- 822-89-9
- Molecular formula:
- C5H5NO2
- IUPAC Name:
- 1-hydroxy-1,2-dihydropyridin-2-one
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: batch A0103550
- Expiration date of the lot/batch: 01/10/2003
- Purity: 98.9%
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: Room temperature in the dark
- Stability under test conditions: Stable - Radiolabelling:
- no
Study design
HPLC method
- Details on study design: HPLC method:
- EQUIPMENT
- Apparatus: Column
- Type, material and dimension of analytical (guard) column: Hypersil BDS-CN; 150 x 4.6 (ID) mm; dp=5 µm (Alltech, Deerfield, USA)
- Detection system: UV at 210 nm
- Column temperature: 35°C
MOBILE PHASES
- Type: 55/45 methanol/0.05 M phosphate buffer added to 400 mL Milli-Q water, adjusted to pH 7.0 with 1 M sodium hydroxide and filled to 450 mL with Milli-Q water.
- pH: 7
- A solution of the reference substance in methanol, at a concentration of 1.5 g/L was used. This solution was diluted by a factor of 100 with mobile phase. As reference blank solution, 99/1 (v/v) mobile phase/methanol was used.
- A 5.3 g/L solution of formamide in methanol was diluted by a factor 10 with mobile phase. This solution was used for the determination of t0 (retention time of the unretarded component). As blank formamide solution, 10% methanol in mobile phase was used.
- A 1.1 g/L stock solution of Oxypyrion was prepared in mobile phase. The test solution was prepared by diluting the stock solution by a factor 10 with mobile phase. As blank solution mobile phase was used.
REFERENCE SUBSTANCES
- Identity: Phenol
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 1 µL
- Quantity of reference substances: 1 µL
REPETITIONS
- Number of determinations: two for the reference substance and the test item solution, and one for the mobile phase, the blank solution and the formamide solution
EVALUATION
- Calculation of capacity factors k': the capacity factor is calculated from the retention of the substance concerned and the unretarded component.
- Determination of the log Koc value: Using the capacity factors of the reference substances, a plot of log Koc (x-value) versus log k' (y-value) was constructed, using linear regression analysis. The log Koc value of each component of the test substance was calculated from the following equation: log k'= a * log Koc + b
Batch equilibrium or other method
- Analytical monitoring:
- no
Results and discussion
Adsorption coefficientopen allclose all
- Key result
- Type:
- Koc
- Value:
- < 21 dimensionless
- pH:
- 7
- Temp.:
- 35 °C
- Key result
- Type:
- log Koc
- Value:
- < 1.3 dimensionless
- pH:
- 7
- Temp.:
- 35 °C
Results: HPLC method
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: 2.3 minutes
- Graph of regression line attached: no
- Average retention data for test substance: 5 minutes
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The HPLC method (OECD 121) using soil-adsorption-reference data was applied for the determination of the adsorption coefficient (Koc) of Oxypyrion. Testing with the ionised form was performed at pH 7. In the chromatogram of Oxypyrion, a broad tailing peak was observed. Because retention time of the major part of the peak was smaller than the retention time of the reference substance phenol, it was concluded that at pH 7 the adsorption coefficient of the test substance (Koc) is < 21 (log Koc < 1.3). The results of the test can be considered reliable without restriction.
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