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Diss Factsheets
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EC number: 209-008-0 | CAS number: 552-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Immunotoxicity
Administrative data
Description of key information
A single study report is available. The study was conducted using Sprague Dawley rats as the test species exposed to the test substance for a 13 week period via inhalation.
Key value for chemical safety assessment
Additional information
Leach, Hatoum, Zeiss and Garvin (1989) examined the immunological effects of Trimellitic Anhydride in Sprague Dawley rats following two weeks exposure via inhalation. The results of this long-term inhalation exposure indicated that sustained immunological tolerance resulted from the exposure. Although TMA-specific antibody was present in small amounts, continued challenges with TMA did not produce TMA lesions. In addition to this, there was no evidence of chronic lung disease such as fibrosis. Rats exposed for 13 weeks and allowed to recover for 3 weeks showed increased antibody titres but few lesions even after a challenge with the test substance. Rats exposed for 13 weeks and allowed to recover for 38 weeks had reduced but still significant antibody titres, however, non-lung lesions were noted even after challenge with Trimellitic Anhydride prior to termination.
These results indicated that rats became tolerant to TMA and that 13 weeks of exposure to TMA did not produce lesions of any type even after 38 weeks of recovery.
Justification for classification or non-classification
Due to the nature of the report, it was not possible to classify the substance.
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