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Diss Factsheets
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EC number: 208-047-0 | CAS number: 506-61-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The conduct of both in vivo and in vitro skin sensitisation tests was waived principally on the basis of the positive result in the in vitro human epidermis (he-EpiDerm) conducted in accordance with OECD431 test guideline.
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the available information indicates that the substance should be classified for respiratory sensitisation or corrosivity
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
According to GHS and EU CLP 1272/2008, potassium dicyanoargentate is classified as category 1A for skin corrosion, as an adverse effect was observed within an hour with 3 minutes of exposure to the substance. - Reason / purpose for cross-reference:
- data waiving: supporting information
- Endpoint:
- skin sensitisation: in vitro
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- the study does not need to be conducted because the available information indicates that the substance should be classified for respiratory sensitisation or corrosivity
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
According to GHS and EU CLP 1272/2008, potassium dicyanoargentate is classified as category 1A for skin corrosion, as an adverse effect was observed within an hour with 3 minutes of exposure to the substance. In addition, the two guideline in vitro studies that could be conducted for this endpoint were considered to be unsuitable. It is advised that no one in vitro study should be considered on its own to cover this endpoint. The two guideline studies available were identified as OECD442C (In chemico Skin Sensiisation: Direct Peptide Reactivity Assay (DPRA)) and OECD442D (In vitro Skin Sensitisation: ARE-Nrf2 Luciferase Test Method (KeratinoSens)). The DPRA method is considered to evaluate the Molecular Initiating event (MIE) stage of the skin sensitisation Adverse Outcome Pathway (AOP) whereas the KeratinoSens method evaluates the second phase of the AOP looking at specific cell signalling pathways in the process. The DPRA method is not applicable for the testing of metal compounds since they are known to react with proteins with mechanisms other than covalent binding, and the KeratinoSens method should not be considered on its own.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no study available
- Additional information:
The conduct of an in vivo skin sensitisation test in the mouse (LLNA, OECD229) was waived on the basis of positive skin corrosion result in the in vitro human epidermis study (OECD431). The potential for conducting in vitro alternatives for this endpoint was considered, however, the two available guideline tests were found to be unsuitable. It is advised that no one in vitro study should be considered on its own to cover this endpoint. The two guideline studies available were identified as OECD442C (in chemico Skin Sensitisation: Direct Peptide Reactivity Assay (DPRA)) and OECD442D (in vitro Skin sensitisation: ARE-Nrf2Luciferase Test Method (KeratinoSens™)). The DPRA method is considered to evaluate the Molecular Initiating Event (MIE) stage of the Adverse Outcome Pathway (AOP) whereas the KeratinoSens™ method evaluates the second phase of the AOP looking at specific cell signalling pathways in the process. The DPRA method is not applicable for the testing of metal compounds since they are known to react with proteins with mechanisms other than covalent binding, and the KeratinoSens™ method should not be considered on its own.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
No specific test to evaluate sensitisation could be conducted as a consequence of the corrosive nature of the test substance or because of the unsuitability of in vitro alternative tests. Therefore, the test substance could not be classified for this endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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