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EC number: 205-840-3 | CAS number: 155-04-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
The test substance ZMBT showed a practically non-irritating potential to rabbit skin (Monsanto Co. 1975). The even very low skin irritation potential is confirmed by another skin irritation study (TNO 1976). A low eye irritation potential of ZMBT was revealed in an eye irritation study with New Zealand albino rabbits (Monsanto Co 1975). The low potential was confirmed in another eye irritating study (TNO 1976).
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: limited but acceptable documented study report which meets basic scientific principles
- Principles of method if other than guideline:
- Method: other: primary skin irritation study, 24 hours exposure; 7-d observation period
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- New Zealand White
- Type of coverage:
- semiocclusive
- Preparation of test site:
- other: intact and abraded
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Duration of treatment / exposure:
- 24 h
- Observation period:
- 7 d
- Number of animals:
- 6
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24 h, 72 h
- Score:
- 0
- Max. score:
- 8
- Reversibility:
- other: no effects
- Remarks on result:
- other: no skin irritating effects observed
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Executive summary:
The skin irritation potential of the test substance ZMBT was evaluated in a skin irritation study with six New Zealand Albino rabbits. The finely ground test substance (0.5 mg) moistened with water was applied under semi-occlusive dressings to clipped intact and abraded skin of 6 New Zealand albino rabbits for 24 hours. A 7 day observation period followed the test substance application. The test substance ZMBT was practically non-irritating to rabbit skin (mean irritation score intact and abraded skin 24 and 72 h average: 0).
Reference
No skin irritating effects observed in any of the treated animals.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Skin
Non-human information
The skin irritation potential of the test substance ZMBT was evaluated in a skin irritation study with six New Zealand Albino rabbits (Monsanto Co.1975). The finely ground test substance (0.5 mg) moistened with water was applied under semi-occlusive dressings to clipped intact and abraded skin of 6 New Zealand albino rabbits for 24 hours. A 7 day observation period followed the test substance application. The test substance ZMBT was practically non-irritating to rabbit skin (mean irritation score intact and abraded skin 24 and 72 h average: 0).
The very slight skin irritating effect of ZMBT was confirmed by another skin irritating study with rabbits (TNO1976). The primary irritation to the skin was measured by a patch-test technique on the abraded and intact skin of albino rabbits. Twelve healthy adult New Zealand White albino rabbits were used. An amount of 0.5 g of the test substance was brought on the intact or abraded skin. Six rabbits were treated on the intact skin, the other six on the abraded skin. The abrasions are minor incisions through the stratum corneum, but not sufficiently deep to disturb the derma or to produce bleeding. After an exposure period of 24 hours the patches and the material applied are removed and the resulting skin reactions were evaluated. A second reading was made 48 hours later (72 hours after application). Slight and transient skin irritating effects were noted in half of the treated animals, indicated by an average score of 1.0/8 for intact skin and an average score of 1.3/8 for abraded skin. The effects were reversible within 72 hours.
Eye
Non-human information
The eye irritating potential of the test substance ZMBT was evaluated in an eye irritation study with six New Zealand albino rabbits (Monsanto Co 1975). The finely ground test substance (100 mg) was placed into eyes of six rabbits. A 7-day observation period followed the application of the test substance. Eye response were scored in accordance with the Federal Hazardous substances Act (F.H.S.A.), 21 CFR, § 191.12 (1964).
The test substance was slightly irritating to the rabbit eye (mean irritation score 24, 48, and 72 hours: 1.8/110.0). Effects on the conjunctivae were noted in all animals at 1 and 24 hours (mean score 1 h: 7.3/110, 24 h: 5.3/110) but were reversible within 48 hours. The test substance was not classified as eye irritating.
The slight and transient eye irritating effects of ZMBT was also observed in another eye irritation study (TNO 1976). Six New Zealand White albino rabbits were used for the test. The test substance (100 mg) was administrated in one eye of each rabbit; whereas the other eye of each rabbit remained untreated and served as control. The eyes are not washed following instillation. The eyes were examined at 24, 48 h, 72 h and 7 days after instillation of the test material. Slight and transient effects on the conjunctivae were noted 24 hours after instillation of the test substance (conjunctivae mean score at 24 h: 0.7/3, chemosis mean score at 24 h: 0.2/4). The effects were fully reversible within seven days.
Justification for classification or non-classification
No classification is required according to the classification criteria 67/548/EWG and regulation no. 1272/2008 (GHS).
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