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EC number: 205-159-1 | CAS number: 134-84-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 14.09.2011 to 16.09.2011
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented GLP study according to OECD guideline 202; study conducted with benzophenone, a substance with a closely related structure and very similar physico-chemical properties
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Methanone, diphenyl-
- IUPAC Name:
- Methanone, diphenyl-
- Reference substance name:
- Benzophenone
- EC Number:
- 204-337-6
- EC Name:
- Benzophenone
- Cas Number:
- 119-61-9
- Molecular formula:
- C13H10O
- IUPAC Name:
- benzophenone
Constituent 1
Constituent 2
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- The concentration of the test item in the aqueous phase of the test was assessed by chemical analysis. Test samples were analysed from fresh media at test start and at 24h. Samples of aged test media were analysed after 24h and at the end of the test. All test concentrations and the control were analysed.
Test solutions
- Vehicle:
- no
- Details on test solutions:
- The test item was distributed to the replicate beakers using an aqueous stock solution. The stock solution (50.1 mg test item/L) was prepared in dilution water and stirred for 24 h. The individual test solutions were prepared by dilution of the stock solution with dilution water and distributed to the test beakers.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- 4-24 hours old (juvenile) , breeding at test facility.
Study design
- Test type:
- semi-static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- None
Test conditions
- Hardness:
- The total hardness of the dilution water (1.3 mmol/L equivalent to 107mg CaCO3) was below the recommended level of 140mg/L. However, the suitability of the soft dilution water has been demonstrated in former acute immobilisation tests on the same species.
- Test temperature:
- The water temperature ranged between 20.3°C and 20.7°C.
- pH:
- The pH values throughout the test were within a range of pH 7.6 – 8.6 at all treatment levels.
- Dissolved oxygen:
- The oxygen saturation was between 7.8 mg/L and 8.7 mg/L.
- Salinity:
- Conductivity was 314.0 µS/cm
- Nominal and measured concentrations:
- Nominal concentrations: 2.1, 4.7, 10.3, 22.7, and 50.1mg/L.
Maesured concentrations: 2.1, 4.47, 8.78,17.9, and 37.4mg/L. Due to recovery rates outside the range of 80 – 120 % of nominal for the highest treatmentmean measured concentrations were applied for effect assessment. - Details on test conditions:
- Four replicates per treatment with 5 specimens per replicate were conducted.
- Reference substance (positive control):
- yes
- Remarks:
- K2Cr2O7
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 6.784 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Remarks on result:
- other: 5.514-8.327
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 4.47 mg/L
- Nominal / measured:
- meas. (arithm. mean)
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
Any other information on results incl. tables
Immobilizationafter 24 h and 48 h. Mean values [%].
Concentrations given as mean measured.*significantdifference when compared with control.
Incubation | Control | 2.1mg/L | 4.47mg/L | 8.78mg/L | 17.9mg/L | 37.4mg/L |
24 h | 0 | 0 | 5 | 45 | 100 | 100 |
48 h | 0 | 5 | 10 | 70 | 100 | 100 |
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The means of initial and aged measured concentrations were 2.1, 4.47, 8.78,17.9, and 37.4mg/L, corresponding with 100, 95, 85, 79, and 75 % of the nominal loading.
The study resulted in a NOEC of 4.47mg/L and in an EC50 of 6.784 mg/L (95% CL = 5.514 – 8.327). Based on the similar structure and physico-chemical properties a very similar fate and behavior of 4 -methylbenzophenone can be assumed. Therefore it can be concluded that the acute toxicity of 4 -methylbenzophenone will be very similar to that of benzophenone. Therefore, and furthermore with respect to animal welfare, the performance of any new experimental tests on 4-methylbenzophenone is assumed to be not justifiable. Instead, results from reliable key studies performed with benzophenone can be regarded as a sound basis for assessing the environmental effects of 4-methylbenzophenone.. - Executive summary:
The GLP study was performed acc. to OECD 202. Nominal test item concentrations of benzophenone were 2.1, 4.7, 10.3, 22.7, and 50.1 mg/L. The chemical analysis showed that the mean measured test item concentrations were between 68 % and 93 %, and 103 % and 111 % of nominal loadings,respectively. The means of initial and aged measured concentrations were 2.1, 4.47, 8.78,17.9, and 37.4mg/L, corresponding with 100, 95, 85, 79, and 75 % of the nominal loading.
The study resulted in a NOEC of 4.47 mg/L and in an EC50 of 6.784 mg/L (95% CL = 5.514 – 8.327).
Based on the similar structure and physico-chemical properties a very similar fate and behavior of 4 -methylbenzophenone can be assumed. Therefore it can be concluded that the acute toxicity of 4 -methylbenzophenone will be very similar to that of benzophenone. Therefore, and furthermore with respect to animal welfare, the performance of any new experimental tests on 4-methylbenzophenone is assumed to be not justifiable. Instead, results from reliable key studies performed with benzophenone can be regarded as a sound basis for assessing the environmental effects of 4-methylbenzophenone.
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