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EC number: 203-499-5 | CAS number: 107-52-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 310 (Ready Biodegradability - CO2 in Sealed Vessels (Headspace Test)
- GLP compliance:
- yes
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- activated sludge, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge (e.g. location, sampling depth, contamination history, procedure): Activated sludge was collected from the Cambridge Wastewater Treatment Facility, Cambridge, Maryland on March 30, 2009. The Cambridge facility treats predominantly residential wastes.
- Preparation of inoculum for exposure: The sludge was sieved using a 2-mm screen and then aerated at test temperature until its adjustment. The activated sludge was diluted in test medium to approximately 30 mg total suspended solids/L and aerated with CO2-free air until its adjustment. The inoculated medium used in the test was prepared by diluting the preconditioned activated sludge in test medium to 4 mg total suspended solids/L. - Duration of test (contact time):
- 28 d
- Initial conc.:
- 20 mg/L
- Based on:
- DOC
- Parameter followed for biodegradation estimation:
- CO2 evolution
- Details on study design:
TEST SYSTEM
- Culturing apparatus: glass serum bottles with a nominal volume of 160 mL. The chambers were sealed with butyl rubber septa and crimp caps.
SAMPLING
- Sampling frequency: Replicate chambers from the control, reference and treatment groups were removed for IC analysis once a week over the test period. Replicate chambers from the toxicity control group were removed for IC analysis on Days 1 and 28. Three replicate test chambers from each group were analyzed at each respective sacrifice interval, except for the last interval (5 replicates each).
- Sampling method: Samples for analysis were prepared by converting CO2 to carbonate. One milliliter of 7M NaOH was injected into the test chambers, which were subsequently shaken for at least 1 hour at test temperature. After mixing, the chambers were removed from the shaker table, allowed to settle and then samples were removed for IC analysis.- Reference substance:
- benzoic acid, sodium salt
- Parameter:
- % degradation (CO2 evolution)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- Test substance: -3.7% in 28 days
Reference substance: 96.5% in 28d (>60% in 7 days)
Toxicity control: 46.2% in 28d - Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- 0% biodegradation in 28 days was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP.
Reference
Table 1: Inorganic carbon concentration (mg C/l) and calculated % biodegradation for inoculum blank, reference substance, test substance and toxicity control
Type of suspension |
1d |
7d |
14d |
21d |
28d |
|
|||||
Inorg. C (mgC/l) |
(%) biodeg |
Inorg. C (mgC/l) |
(%) biodeg |
Inorg. C (mgC/l) |
(%) biodeg |
Inorg. C (mgC/l) |
(%) biodeg |
Inorg. C (mgC/l) |
(%) biodeg |
Cumulative average (%) biodeg (Day 28) |
|
|
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Inoculum Blank |
- |
- |
0.3; 0.1; 0.4 |
- |
2.3; 2.4; 1.8 |
- |
2.9; 2.8; 3.1 |
- |
2.8; 2.8; 3.1; 2.6; 3.1 |
- |
- |
|
|
|
|
|
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|
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Reference substance |
- |
- |
16.9; 16.8; 17.4 |
83.8; 83.4; 86.1 |
18.8; 19.5; 19.1 |
84.1; 87.4; 85.4 |
20.5; 20.4; 20.4 |
88.4; 88.2; 88.2 |
22.1; 22.0; 22.2; 21.9; 21.9 |
96.7; 96.3; 97.5; 96.1; 95.8 |
96.5 |
|
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|
|
|
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Test substance |
- |
- |
0.1; 0.0; 0.0 |
-0.7; -1.3; -1.5 |
1.9; 2.3; 1.5 |
-1.5; 0.4; -3.2 |
2.4; 2.3; 2.4 |
-2.9; -3.2; -2.6 |
2.2; 2.2; 2.4; 2.1; 2.0 |
-3.5; -3.7; -2.6; -3.9; -4.6 |
-3.7 |
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Toxicity control |
13.4; 13.6; 13.6 |
33.7; 34.3; 34.4 |
- |
- |
- |
- |
- |
- |
21.3; 21.1; 21.1; 21.4; 20.9 |
46.6; 46.0; 45.9; 46.8; 45.5 |
46.2 |
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Description of key information
Biodegradation in water: screening tests: 0% in 28 days (OECD 310), read-across from a structurally-related substance.
Key value for chemical safety assessment
- Biodegradation in water:
- under test conditions no biodegradation observed
Additional information
There are no reliable ready biodegradation data available for tetradecamethylhexasiloxane (L6), therefore good quality data for the structurally-related substance, octamethyltrisiloxane (L3, CAS No. 107-51-7), have been read across. L6 and L3 are structurally-similar substances, both are linear siloxanes.
L3 is a linear siloxane chain with three silicon atoms, connected by two oxygen atoms. All silicon atoms present are fully substituted with methyl groups. L6 is a structurally related linear siloxane, with six silicon atoms and five oxygen atoms.
L3 and L6 are within a group of substances within which, in general, there is no evidence of any significant biodegradation.
The table below presents ready biodegradation data for substances within the group of siloxanes (alkyl, vinyl, aryl or hydrogen substituted).
It is therefore considered valid to read-across the results for L3 to fill the data gap for the registered substance. Additional information is given in a supporting report (PFA, 2017at) attached in Section 13.
Table 4.5: Ready biodegradation data for substances within the siloxane group
CAS |
Name |
Readily biodegradable? Yes/no |
Result: Biodegradation after 28 days (%)* |
Guideline |
Test type |
Reliability |
107-46-0 |
Hexamethyldisiloxane |
No |
2% |
OECD 301C |
BOD |
1 |
107-51-7 |
Octamethyltrisiloxane |
No |
-3.70% |
OECD 310 |
CO2 |
1 |
540-97-6 |
Dodecamethylcyclohexasiloxane |
No |
4.5% |
OECD 310 |
CO2 |
1 |
541-02-6 |
Decamethylcyclopentasiloxane |
No |
0.14% |
OECD 310 |
CO2 |
1 |
541-05-9 |
Hexamethylcyclotrisiloxane |
No |
0.06% |
OECD 310 |
CO2 |
1 |
556-67-2 |
Octamethylcyclotetrasiloxane |
No |
3.70% |
OECD 310 |
CO2 |
1 |
1873-88-7 |
1,1,1,3,5,5,5-Heptamethyltrisiloxane |
No |
0% |
OECD 310/ ISO Guideline No 14593 |
CO2 |
1 |
2627-95-4 |
1,1,3,3-Tetramethyl-1,3-divinyldisiloxane |
No |
0% |
OECD 301D |
BOD |
1 |
17928-28-8 |
1,1,1,3,5,5,5-Heptamethyl- 3-[(trimethylsilyl)oxy] trisiloxane |
No |
0% |
OECD 301F |
BOD |
1 |
17955-88-3 |
1,1,1,3,5,5,5-Heptamethyl-3-octyltrisiloxane |
No |
10 – 32 % after 25 d |
OECD 301B |
CO2 |
1 |
60111-47-9 |
3-[(Dimethylvinylsilyl)oxy]-1,1,5,5-tetramethyl-3-phenyl-1,5-divinyltrisiloxane |
No |
2.20% |
OECD 301F |
BOD |
1 |
69304-37-6 |
1,3-Dichloro-1,1,3,3-tetraisopropyldisiloxane |
No |
0% (BOD); 100% (GC) |
OECD 301C |
BOD |
1 |
70940-00-0 |
1,1,7,7,-Tetramethyl-3,3,5,5,-Tetraphenyl-Tetrasiloxane |
No |
9.7 and 9.9% |
OECD 301B |
CO2 |
1 |
180073-46-5 |
Pentasiloxane, 1,1,9,9-tetramethyl-3,3,5,5,7,7-hexaphenyl- |
No |
5.2 and 4.4% |
OECD 301B |
CO2 |
1 |
352230-22-9 |
Siloxanes and Silicones, di-Ph, Ph (trimethylsilyl)oxy |
No |
0% |
OECD 301F |
BOD |
1 |
In the study with L3, 0% biodegradation was observed in 28 days.
The study was conducted according to OECD 310 and is considered reliable. This is selected as the key study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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