Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-327-9 | CAS number: 105-75-9
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
Additional information
Toxicity Summary
Acute oral toxicity:
The acute oral toxicity (LD50) is 8530 mg per kg body weight in rats.
Acute dermal toxicity:
The acute dermal toxicity (LD50) is 15.9 mL per kg body weight in rabbits.
Acute toxicity, inhalation:
Rats exposed for 8 hours to saturated vapours of the test substance survived. No mortalities occurred. Therefore the acute toxicity via inhalation is considered to be very low.
Repeated dose toxicity:
NOAEL (rat, oral, 90 d) = 50 mg/kg bw/day (adverse effects kidney)
Reproductive toxicity
NOAEL (rat, developmental toxicity) > 750 mg/kg bw/day (highest dose tested, no developmental toxicity reported)
NOAEL (rat, maternal toxicity) = 250 mg/kg bw/day (body weight and food intake)
Genetic toxicity
The test item gave negative results in one bacterial gene mutation test, one in vitro cytogenetic study and one in vitro gene mutation study, regardless whether tested without or with the addition of metabolizing enzymes.
Toxicokinetic summary
Absorption / distribution
No indication for absorption in the gastrointestinal tract are derived from the results of the acute oral toxicity study. Although the log Pow is relatively high (4.62) and the water solubility is low (11.09 mg/L) uptake via the skin is considered to be low (LD50,dermal,rabbit 15.9 mL/kg bw).
Metabolism
No relevant differences occurred in the three mutagenicity studies with and without the addition of a metabolising system. Therefore no indication of the importance of the metabolism of the test item was obtained from these studies. DBF is expected to be metabolized rapidly in the human body and there is no expectation of desintegration into toxic cleavage products.
Excretion
No information is available on excretion of the test item.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
