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EC number: 202-928-3 | CAS number: 101-25-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
REACH_LD50 = 940 mg/kg bw | rat | - | #WoE#
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1967
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 6w oral and i.p. administration including preliminary experiments on acute i.p. toxic effects; acute poisening test (Bordas and Sziza)
- GLP compliance:
- no
- Test type:
- other: not specified
- Limit test:
- no
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- other: oral: unspecified and i.p.
- Vehicle:
- other: aqueous suspension stabilized with acacia gum
- Details on oral exposure:
- no further details
- Doses:
- Acute oral: 940 mg/kg
Acute i.p.: 640, 420, 280, 200 mg/kg
Subacute i.p.: 180, 150, 120, 80 mg/kg/d - No. of animals per sex per dose:
- Acute oral/i.p.: not specified in detail (i.p. 1-6)
Subacute: 6 EEG group, 10 conditioned reflex group - Control animals:
- other: vehicle control group in the subacute experiment
- Details on study design:
- Acute toxicity was tested in preliminary experiments (oral and i.p., not specified in detail).
In the main experiment, the subacute i.p. toxicity regarding nervous effects was tested in rats including an EEG group and a conditioned reflex group. - Statistics:
- Not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 940 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- LD50
- Remarks:
- subacute (6 w)
- Effect level:
- 253 mg/kg bw
- Based on:
- test mat.
- Sex:
- not specified
- Dose descriptor:
- LD100
- Remarks:
- subacute (6w)
- Effect level:
- 470 mg/kg bw
- Based on:
- test mat.
- Mortality:
- Not specified in detail
- Clinical signs:
- other: Preliminary test (acute i.p.): spasmodic attacks; acute oral no details Subacute experiment: At beginning free of symptoms then sudden onset of spasms
- Gross pathology:
- No data for acute administration
- Other findings:
- Subacute experiment: Changes in the nervous system at higher doses i.p.
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- The acute oral toxicity was tested in preliminary experiments resulting in a LD50 of 940 mg/kg bw.
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- No details reported
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Specific details on test material used for the study:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Doses:
- 2.9 g/kg bw
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 900 mg/kg bw
- Mortality:
- LD50 exceeded 2.9 g/kg bw in rats; no further details
- Clinical signs:
- other: Poisening was accompanied by convulsions, tremor, respiratory system damage
- Gross pathology:
- not specified
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 exceeded 2.9 g/kg bw in rats.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 940 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Acute oral Toxicity
The LD50in an acute oral toxicity study was determined to be 940 mg/kg. Other authors reported an LD50> 2900 mg/kg in rats. Effects seen were convulsions, tremor and respiratory tract damage. Available information indicate that classification for acute oral toxicity category 4 is warranted.
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