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EC number: 201-082-2 | CAS number: 78-09-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
- Preliminary study:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 7 060 mg/kg bw
- Remarks on result:
- other:
- Remarks:
- LD50 value is >2000
- Mortality:
- not specified
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat. The read-across of these data is considered as justified.
- Executive summary:
The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat.
- Endpoint:
- acute toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point - Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate)
- GLP compliance:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 7 060 mg/kg bw
- Based on:
- not specified
- Remarks on result:
- other:
- Remarks:
- LD50 value is 7060 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No data are available for substance target (TEC); however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat. The read-across of these data is considered as justified.
- Executive summary:
The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 7 060 mg/kg bw
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remark on MMAD/GSD:
- not specified
- Details on inhalation exposure:
- not specified
- Remarks on duration:
- not specified
- Concentrations:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
- Preliminary study:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- ca. 26.1 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 8 h
- Remarks on result:
- other:
- Remarks:
- LCLo value equal to 26,1 mg/L in rat. This parameter has been estimated following to 8h-exposure
- Mortality:
- not specified
- Clinical signs:
- other: not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat. This parameter has been estimated following to 8h-exposure. The read-across of these data is considered as justified
- Executive summary:
The triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat.
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point - Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate)
- GLP compliance:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- ca. 26 mg/L air
- Based on:
- not specified
- Exp. duration:
- 8 h
- Remarks on result:
- other:
- Remarks:
- LCLo value equal to 26,1 mg/L in rat
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat. This parameter has been estimated following to 8h-exposure. The read-across of these data is considered as justified.
- Executive summary:
The triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 26.1 mg/m³
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point - Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- not specified
- No. of animals per sex per dose:
- not specified
- Control animals:
- not specified
- Details on study design:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 18 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- LD50 value is equal to 18000 mg/kg bw
- Mortality:
- not specified
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 18000 mg/kg bw in rabbit. The read-across of these data is considered as justified
- Executive summary:
The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 18000 mg/kg bw in rabbit.
- Endpoint:
- acute toxicity: dermal
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2012
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- The read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate) is based on the following hypothesis:
- chemical source and chemical target have the same organic functional groups; the only difference is the aliphatic carbon of the chemical source no judged relevant for this evaluation
- chemical source and chemical target have a very close structure similarity
- chemical source and chemical target have similar flash point and boiling point - Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- Read-across of data from chemical source (triethyl orthoformate) to chemical target (Tetraethyl orthocarbonate)
- GLP compliance:
- not specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- ca. 18 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other:
- Remarks:
- LD50 value equal to 18000 mg/kg bw
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- No data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 18000 mg/kg bw in rabbit. The read-across of these data is considered as justified
- Executive summary:
The triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 18000 mg/kg bw in rabbit.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 180 000 mg/kg bw
Additional information
Justification for classification or non-classification
Acute toxicity - oral
no data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 7060 mg/kg bw in rat. The read-across of these data is considered as justified.Overall, This end-point is judged as concl no class.
Acute toxicity - dermal
no data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LD50 value equal to 18000 mg/kg bw in rabbit. The read-across of these data is considered as justified. Overall, This end-point is judged as concl no class.
Acute toxicity - inhalation
no data are available for the tetraethyl orthocarbonate; however, the triethyl orthoformate (a structural analogue substance) has a LCLo value equal to 26,1 mg/L in rat. This parameter has been estimated following to 8h-exposure. The read-across of these data is considered as justified. Overall, This end-point is judged as concl no class.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.