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EC number: 200-898-6 | CAS number: 75-75-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Link to relevant study records
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP Guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- modified grading timings for evaluation
- GLP compliance:
- yes
- Type of study:
- Buehler test
- Species:
- guinea pig
- Strain:
- Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Harlan Sprague-Dawley Inc. (P.O. Box 29176, Indianapolis, Indiana 46229)
- Weight at study initiation: 429.6±18.8 g (males), 400.5±27.6 g (females)
- Housing: single
- Diet (e.g. ad libitum): Teklad Guinea Pig Diet
- Water (e.g. ad libitum): tap water
- Acclimation period: 4 days
ENVIRONMENTAL CONDITIONS
- Photoperiod (hrs dark / hrs light): 12/12 - Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- Induction: 35 % MSA
Challenge: 17.5 % MSA - Route:
- epicutaneous, occlusive
- Vehicle:
- water
- Concentration / amount:
- Induction: 35 % MSA
Challenge: 17.5 % MSA - No. of animals per dose:
- 10 males, 10 females (controls: 5 males, 5 females)
- Details on study design:
- RANGE FINDING TESTS:
A preliminary study was conducted in order to determine the concentrations to be tested in the main study. The irritation potential of methane sulfonic acid (MSA) 70 % at levels of undiluted, 50 %, 25 %, 10 %, 5 %, 2.5 %, 1.0 % and 0.5 % was evaluated in 2 groups of 4 animals each. Four levels of test substance were evaluated per animal. Dilutions were obtained with distilled water (w/v). 0.3 ml of the different concentrations were applied into 25 mm Hill Top Chambers, which were placed on the animals clipped back for 6 hours. On the next day the animals were depilated and two hours later examined for irritation, according to the grading scores (0: no reaction; : slight, patchy erythema; 1: slight but confluent or moderate patchy erythema; 2: moderate erythema; 3: severe erythema with or without edema). Another examination was performed 40 hours after exposure. Undiluted 70 % produced grades of 2,1 and ± with edema, blanching, and scabbing on two sites, 50 %, 25 %, 10 %, 5 %, 2.5 %, 1.0 % produced grades of ±, while 0.5% produced grades of ± and 0. A 50 % w/v concentration of MSA 70% in distilled water was chosen for use at induction for the test group. The level was chosen as the highest concentration causing no greater than mild to moderate primary irritation.
MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 3
- Exposure period: 6 hours
- Test groups: 0.3 ml of the test substance
- Control group: 0.3 ml vehicle
- Site: left shoulder
- Frequency of applications: on day 1, 7 and 14
- Duration: 14 days
- Concentrations: 50 % (w/v of MSA 70%)
B. CHALLENGE EXPOSURE
- No. of exposures: 1
- Day(s) of challenge: 28
- Exposure period: 24 hours
- Test groups: 0.3 ml of test substance
- Control group: 0.3 ml of test substance
- Site: right flank
- Concentrations: 25 % (w/v of MSA 70%)
- Evaluation (hr after challenge): 24 hours - Challenge controls:
- No extra group necessary: control group was challenged with test substance, as well, because induction exposure with distilled water is not expected to induce any sensitization.
- Positive control substance(s):
- no
- Reading:
- 1st reading
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 17.5 %
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no clinical signs
- Remarks on result:
- other: Reading: 1st reading. . Hours after challenge: 24.0. Group: test group. Dose level: 17.5 %. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: no clinical signs.
- Reading:
- 2nd reading
- Hours after challenge:
- 40
- Group:
- test chemical
- Dose level:
- 17.5%
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Clinical observations:
- no clinical signs
- Remarks on result:
- other: Reading: 2nd reading. . Hours after challenge: 40.0. Group: test group. Dose level: 17.5%. No with. + reactions: 0.0. Total no. in groups: 20.0. Clinical observations: no clinical signs.
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information
Reference
None of the test animals responded with a skin grade that would have been suggestive of sensitization. No data on clinical signs was revealed.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
According to the information requirements for REACH (column 2 of Annex VIII) in vivo testing for skin sensitisation does not need to be conducted because the substance is classified as corrosive to the skin (pH <2).
Nevertheless, key information is available from a study (ElfAtochem 1995) stating that the substance did not cause skin sensitisation in guinea-pigs in the Buehler Test following the OECD test guideline 406. Ten male and ten female guinea pigs received 3 induction exposures via topical dermal application with 0.3 ml of 35 % methanesulfonic acid on their left shoulder for 6 hours on day 1, 7 and 14. On day 28, the animals were epicutaneously treated for 24 hours with 0.3 ml of 17.5 % methanesulfonic acid on their right flank as challenge exposure. None of the test animals responded with a skin grade that was suggestive of sensitization.
Summerising the substance is not a skin sensitizer in an animal test.
Migrated from Short description of key information:
Methanesulphonic acid (MSA) is not sensitizing in a OECD 406 (Bühler Test).
Respiratory sensitisation
Endpoint conclusion
- Additional information:
This information is not available.
Justification for classification or non-classification
Based on the information available, no further classification for sensitisation is needed.
EU classification according to Annex I of Directive 67/548/EEC: no classification required
GHS classification (GHS UN rev.3, 2009): no classification required
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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