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EC number: 270-126-0 | CAS number: 68411-44-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- repeated dose toxicity: oral
- Remarks:
- combined repeated dose and reproduction / developmental screening
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- A 2-generation reproductive toxicity study of n-butylbenzene in rats.
- Author:
- Izumi H, Kimura E, Ota T, and Shimazu S
- Year:
- 2 005
- Bibliographic source:
- J. Tox. Sci. 30:21-38.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Two-Generation Reproductive Toxicity Study in Rats
- Principles of method if other than guideline:
- Two-Generation Reproductive Toxicity Study in Rats
- GLP compliance:
- not specified
Test material
- Reference substance name:
- n-Butylbenzene
- IUPAC Name:
- n-Butylbenzene
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: gavage
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
28-Day Oral Toxicity Study (Preliminary study):
Study observed:
At 1000 mg/kg bw/day: inhibition of body weight gain (males/females).
At >=300 mg/kg bw/day: elevated liver and kidney/adrenal weights (males)
Two-Generation Reproductive Toxicity Study in Rats:
Study observed:
Parental toxicity:
No substance-related mortality was observed.
Clinical signs:
At >=100 mg/kg bw: Salivation (males/females, both F0 and F1).
Organ weights:
At >=30 mg/kg bw/day: increased liver weights (F0 females).
At >=100 mg/kg bw/day: increased liver weights (F0 females).
At 300 mg/kg bw/day: increased liver weights (F1 males/females).
At 300 mg/kg bw/day: increased kidney weights (F0 males/females).
At >=100 mg/kg bw/day: increased liver weights (F1 males).
At 300 mg/kg bw/day: increased kidney weights (F1 females).
Histopathology:
At 300 mg/kg bw/day: centrilobular hepatocytic hypertrophy (F0 and F1 males).
At >=100 mg/kg bw/day: histopathological changes oft he kidney (F0 and F1 males).
NOEL (parental) < 30 mg/kg bw/day;
NOAEL/LOEL (parental) =30 mg/kg bw/day (increased liver weights)
LOAEL (parental) =100 mg/kg bw/day (increased kidney weights and histopathological changes in the kidney).
Reproductive Toxicity:
No substance-related effects on fertility were observed in F0 and F1 parental animals (males/females).
No substance-related effects on the endocrine system were observed.
NOEL and NOAEL (reproductive) =300 mg/kg bw/day
Developmental Toxicity:
At 300 mg/kg bw/day: increased absolute and relative weights of the thymus (F1 and F2 offspring animals).
NOEL and NOAEL (developmental) =100 mg/kg bw/day
LOAEL (developmental)= 300 mg/kg bw/day (increase in the thymus weights seen in F1 and F2 offspring)
Applicant's summary and conclusion
- Conclusions:
- Overall, the liver and kidney are reported as target organs for chronic toxicity of butylbenzene components. The chronic toxicity data observed in the repeated dose toxicity studies with rodents report the following NOAELs/LOAELs for n-butylbenzene:
NOAEL (oral, rats, systemic toxicity) =30 mg/kg bw/day (increased liver weights)
LOAEL (oral, rats, systemic toxicity) =100 mg/kg bw/day (increased kidney weights and histopathological changes in the kidney).
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