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Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 405-820-6 | CAS number: 30025-38-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 4 hours contact, 10 days total
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study - original study report available
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- Principles of method if other than guideline:
- Conformed to recommendations of the OECD Short-Term and Long-Term Toxicology Groups Final Report, Paris 1981; ISBN 92-64-12221-4
- GLP compliance:
- yes
Test material
- Reference substance name:
- -
- EC Number:
- 405-820-6
- EC Name:
- -
- Cas Number:
- 30025-38-8
- Molecular formula:
- C8H18O3
- IUPAC Name:
- reaction mass of 5-methyl-4,7-dioxa-2-nonanol and 6-methyl-4,7-dioxa-2-nonanol
- Reference substance name:
- Dipropylene Glycol Monoethyl Ether
- IUPAC Name:
- Dipropylene Glycol Monoethyl Ether
- Details on test material:
- - Name of test material (as cited in study report): Ethoxypropoxy Propanol (synonym of Dipropylene glycol monoethyl ester).
- Physical state: A clear colourless liquid
- Analytical purity: Not specified
- Impurities (identity and concentrations): Not specified
Purity test date: Not specified
- Lot/batch No. GOHC laboratory Sample No. 1030, Oil Stock Ref. No. 09977, 134/109
- Expiration date of the lot/batch: Not specified
- Stability under test conditions: Not specified.
- Storage condition of test material: At ambient temperature in brown screw-capped bottle.
- Other: None
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: C&J Morton (Stansted Ltd)
- Age at study initiation: ~3 months
- Weight at study initiation: 2.84-2.97 kg
- Housing: Individually in suspended, mesh-floored cages
- Diet (e.g. ad libitum): Commercially available pelleted standard rabbit diet ad libitum
- Water (e.g. ad libitum): mains supply, ad libitum
- Acclimation period: 6 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18 (10-25)
- Humidity (%): 50 (40-75)
- Air changes (per hr): 12 (no recirculation)
- Photoperiod (hrs dark / hrs light): 10/14
IN-LIFE DATES: From: 1985-10-22 TO 1985-10-31
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): neat
VEHICLE
- Amount(s) applied (volume or weight with unit): None - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 24, 48 and 72 hours; 10 days
- Number of animals:
- 3
- Details on study design:
- TEST SITE
- Area of exposure: 3 x 2 cm
- % coverage: 100
- Type of wrap if used: Blenderm (3-M Company)
REMOVAL OF TEST SUBSTANCE
- Washing (if done): warm water and dried with paper towel
- Time after start of exposure: 4 hours
SCORING SYSTEM: After Draize:
ERYTHEMA
No erythema 0
very slight 1
well-defined 2
moderate to severe 3
severe erythema to slight eschar 4
OEDEMA
No oedema 0
very slight 1
slight 2
moderate 3
severe (raised more than 1 mm) 4
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects seen to reverse
- Remarks on result:
- no indication of irritation
- Remarks:
- very slight exfoliation seen at 48hr
- Irritation parameter:
- edema score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects seen to reverse
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects seen to reverse
- Remarks on result:
- no indication of irritation
- Remarks:
- very slight exfoliation seen at 48 hrs
- Irritation parameter:
- edema score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects seen to reverse
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- erythema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects seen to reverse
- Remarks on result:
- no indication of irritation
- Remarks:
- very slight exfoliation seen at 72 hrs
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Reversibility:
- other: no effects seen to reverse
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- Not irritant
- Other effects:
- Occasional exfoliation following slight erythema.
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: Official Journal EC L257/8 Vol 26, 16/9/83 and L257/19. Vol 26, 16/9/83
- Conclusions:
- Not irritating
- Executive summary:
This well conducted key study using OECD method prior to its adoption as method OECD 404 demonstrates a lack of dermal irritancy in this model. Mean maximum scores (1) were below the GHS criteria of >=1.5 for optional classification as Category 3 (mild irritant).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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