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Diss Factsheets
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EC number: 203-187-9 | CAS number: 104-23-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Experimental data of test chemical
- Justification for type of information:
- Experimental data of various test chemical is from handbook
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Refer below principle
- Principles of method if other than guideline:
- WoE report is prepared based on toxicity to bacteria study:
2nd and 3rd - GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- other: Bacteria
- Details on inoculum:
- Unadapted biological waste water treatment plants
- Test type:
- not specified
- Water media type:
- other: Sewage water
- Total exposure duration:
- 24 h
- Details on test conditions:
- 3. Details on test conditions
TEST SYSTEM
- Test vessel: Fermentation tube - Reference substance (positive control):
- not specified
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: 2nd study
- Dose descriptor:
- EC0
- Effect conc.:
- > 2 500 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
- Remarks on result:
- other: 3rd study
- Validity criteria fulfilled:
- not specified
- Conclusions:
- 2. Based on the growth rate inhibition of bacteria after exposure of 24 hrs with the test chemical, no effect were observed on the growth of bacteria. The EC0 was determine at the 500 mg/l.
3. Based on the growth rate inhibition of bacteria after exposure with test chemical, the EC0 was determine at > 2500 mg/l.
Thus based on the overall studies for the test chemical, chemical consider to be nontoxic and the toxicity ranges from the concentration of 500 - 2500 mg/l. - Executive summary:
Various studies available for the test chemical were reviewed to determine the toxic nature of test chemical on the growth and other activity of microorganisms. The studies are as mentioned below:
Aim of this study was to determine the effect of test chemical on the growth of bacteria. Unadapted biological waste water treatment plants were used. Test conducted for 24 hrs. Based on the growth rate inhibition of bacteria after exposure of 24 hrs with the test chemical, no effect were observed on the growth of bacteria. The EC0 was determine at the 500 mg/l. based on the EC0 chemical can be consider to be nontoxic to the growth of microorganisms.
Above study was supported by the second study from peer reviewed journal. Study was conducted to determine the level of effect of test chemical on the growth of bacteria. Based on the growth rate inhibition of bacteria after exposure with test chemical, the EC0 was determine at > 2500 mg/l. As no effect were observed on the growth of bacteria chemical consider to be nontoxic.
Thus based on the overall studies for the test chemical, chemical consider to be nontoxic and the toxicity ranges from the concentration of 500 - 2500 mg/l.
Reference
Description of key information
2. Based on the growth rate inhibition of bacteria after exposure of 24 hrs with the test chemical, no effect were observed on the growth of bacteria. The EC0 was determine at the 500 mg/l.
3. Based on the growth rate inhibition of bacteria after exposure with test chemical, the EC0 was determine at > 2500 mg/l.
Thus based on the overall studies for the test chemical, chemical consider to be nontoxic and the toxicity ranges from the concentration of 500 - 2500 mg/l.
Key value for chemical safety assessment
- EC50 for microorganisms:
- 500 mg/L
Additional information
Various studies available for the test chemical and structually and functionally similar read across chemical were reviewed to determine the toxic nature of test chemical on the growth and other activity of microorganisms. The studies are as mentioned below:
Aim of this study was to determine the effect of test chemical on the growth of bacteria. Unadapted biological waste water treatment plants were used. Test conducted for 24 hrs. Based on the growth rate inhibition of bacteria after exposure of 24 hrs with the test chemical, no effect were observed on the growth of bacteria. The EC0 was determine at the 500 mg/l. based on the EC0 chemical can be consider to be nontoxic to the growth of microorganisms.
Above study was supported by the second study from peer reviewed journal. Study was conducted to determine the level of effect of test chemical on the growth of bacteria. Based on the growth rate inhibition of bacteria after exposure with test chemical, the EC0 was determine at > 2500 mg/l. As no effect were observed on the growth of bacteria chemical consider to be nontoxic.
Thus based on the overall studies for the test chemical, chemical consider to be nontoxic and the toxicity ranges from the concentration of 500 - 2500 mg/l.
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