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Diss Factsheets
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EC number: 701-266-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- no data
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Remarks:
- The study followed methods similar to OECD406. The study was not performed according to GLP. No data on test substance composition/purity. Results are described very limited, only a summary table is presented.
Data source
Reference
- Reference Type:
- publication
- Title:
- Evaluation of skin sensitization and cross-reaction of nine alkyleneamines in the guinea pig maximization test
- Author:
- Leung, H-W., Auletta, C.S.
- Year:
- 1 997
- Bibliographic source:
- J. Toxicol.-Cut. & Ocular Toxicol., 16(3), 189-195
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 406 (Skin Sensitisation)
- Deviations:
- yes
- Remarks:
- insufficient documented
- GLP compliance:
- no
- Type of study:
- guinea pig maximisation test
Test material
- Reference substance name:
- Polyethylene polyamine, pentaethylenehexamine fraction
- EC Number:
- 701-266-7
- Molecular formula:
- Complex UVCB substance
- IUPAC Name:
- Polyethylene polyamine, pentaethylenehexamine fraction
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Name in the publication: pentaethylenehexamine (PEHA, CAS 4067-16-7)
Samples were obtained from the Union Carbide Corporation (South Charleston, WV)
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Dunkin-Hartley
- Sex:
- male/female
Study design: in vivo (non-LLNA)
Induction
- Route:
- intradermal and epicutaneous
- Vehicle:
- water
- Concentration / amount:
- intradermal: 5%
epicutaneous: 100% - Adequacy of induction:
- highest concentration used causing mild-to-moderate skin irritation and well-tolerated systemically
Challenge
- Route:
- epicutaneous, semiocclusive
- Vehicle:
- water
- Concentration / amount:
- 100%
- Adequacy of challenge:
- highest non-irritant concentration
- No. of animals per dose:
- 10 males and 10 females
Results and discussion
In vivo (non-LLNA)
Results
- Group:
- test chemical
- Dose level:
- 100%
- No. with + reactions:
- 19
- Total no. in group:
- 19
- Remarks on result:
- positive indication of skin sensitisation
- Remarks:
- 100% positive
Any other information on results incl. tables
Percentage of animals in the group showing a positive skin response: 100% PEHA had low potency.
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS Category 1 (H317) according to Regulation (EC) No 1272/2008
- Conclusions:
- From the results of this study is can be concluded that the test substance is a skin sensitizer.
- Executive summary:
A group of nine alkyleneamines were investigated for their potential to induce skin sensitization and to cross-react with one another to elicit a hypersensitivity response. Ethylenediamine was the most potent skin sensitizer, and diethylenetriamine was next in potency. The sensitizing potency was inversely correlated with the number of amine units. Cyclic amines such as piperazine had a lower sensitizing potency than the corresponding olefinic amines. Ethylenediamine also produced the strongest response in cross-reactions with other alkyleneamines. The results suggest that there was a direct correlation of the potencies to cause skin irrtation, sensitization, and cross-sensitization in this family of alkyleneamines.
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