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EC number: 701-249-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 16th to 29th September 1996
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Guideline study following GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.5 (Acute Toxicity: Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Phenol, paraalkylation products with C10-15 branched olefins ( C12 rich) derived from propene oligomerization, calcium salts, sulfurized, including distillates (petroleum), hydrotreated, solvent-refined, solvent-dewaxed, or catalyc dewaxed, light or heavy paraffinic C15-C50
- EC Number:
- 701-249-4
- Molecular formula:
- A molecular formula for this substance does not exist because it is a UVCB. The molecular formula for a theoretical representative structure is C36H58Ca2O4Sx where x = 1-3.
- IUPAC Name:
- Phenol, paraalkylation products with C10-15 branched olefins ( C12 rich) derived from propene oligomerization, calcium salts, sulfurized, including distillates (petroleum), hydrotreated, solvent-refined, solvent-dewaxed, or catalyc dewaxed, light or heavy paraffinic C15-C50
- Details on test material:
Phenol, dodecyl-, sulfurized, calcium salts
Testing was performed on a commercial sample of this material. Typical purity of this material as distributed in commerce is 60% alkyl phenol sulfide and 40% highly refined lubricant base oil.
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: Adult albino rabbits of the Hra:(NZW)SPF strain were procured from HRP, Inc., Kalamazoo, Michigan on September 4, 1996.
- Age at study initiation: approximately 14 to 18 weeks of age
- Weight at study initiation: weighing from 2,209 to 2,514 g
- Housing: the animals were individually housed in suspended stainless steel cages
- Diet/water (e.g. ad libitum): The animals were provided access to water ad libitum and a measured amount of Laboratory Rabbit Diet HF #5326, PMI Feeds, Inc. The feed is routinely analyzed by the manufacturer for nutritional components and environmental contaminants. Samples of the water are periodically analyzed. There were no known contaminants in the feed or water at levels that could be expected to interfere with or affect the results of the study.
- Acclimation period: After receipt, the animals were acclimated for a period of at least 7 days.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19° to 23°C
- Humidity (%): 50% ±20%
- Photoperiod (hrs dark / hrs light): 12-hour light/12¬hour dark lighting cycle
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- Dose level: 0.1 ml/one eye/animal
(Group 1, eyes unwashed post dosing N=6, Group 2, eyes washed post dosing N=3), - Duration of treatment / exposure:
- The test material was not washed from the eyes of the animals in Group 1. The treated eyes of the rabbits in Group 2 were flushed with lukewarm tap water for 1 minute starting 30 seconds after test material instillation.
- Observation period (in vivo):
- Treated eyes were examined at 1, 24, 48 and 72 hours after treatment. An additional observation was made at 96 hours after treatment for the
Group 1 animals (unwashed). - Number of animals or in vitro replicates:
- 5 males; 4 females (six were used for group 1 and 3 for group 2)
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): The eyes of the rabbits in Group 1 remained unflushed immediately after treatment while the treated eyes of the rabbits in Group 2 were flushed with lukewarm tap water for 1 minute starting 30 seconds after test material instillation.
SCORING SYSTEM: Irritation was graded and scored according to the Draize technique using a penlight as the source of illumination. A sodium fluorescein examination was used to aid in revealing possible corneal injury at the observation conducted at 24 hours.
TOOL USED TO ASSESS SCORE: sodium fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 24, 48 & 72 hours
- Score:
- 0
- Reversibility:
- other: no effects seen
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 24, 48 & 72 hours
- Score:
- 0
- Reversibility:
- other: no effects seen
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 1.8
- Max. score:
- 2
- Reversibility:
- fully reversible within: 96 hours
- Remarks on result:
- other: Redness
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 48 hours
- Score:
- 0.8
- Max. score:
- 1
- Reversibility:
- fully reversible within: 96 hours
- Remarks on result:
- other: Redness
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 72 hours
- Score:
- 0.2
- Max. score:
- 1
- Reversibility:
- fully reversible within: 96 hours
- Remarks on result:
- other: Redness
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 24 hours
- Score:
- 0.3
- Max. score:
- 1
- Reversibility:
- fully reversible within: 48 hours
- Irritant / corrosive response data:
- The test material when evaluated for its primary eye irritation potential in rabbits, produced a corneal opacity in one animal and conjunctival irritation in all treated eyes that were unwashed after treatment.
- Other effects:
- Two animals exhibited hair loss around the treated eye
Any other information on results incl. tables
The potential eye-irritancy of the substance was investigated in a study conduted in line with OECD guideline 405 under conditions of GLP. The test material when evaluated for its primary eye irritation potential in rabbits, produced a corneal opacity in one animal and conjunctival irritation in all treated eyes that were unwashed after treatment. All treated eyes in this group returned to a normal appearance by 96 hours after treatment with the exception that two animals exhibited hair loss around the treated eye. Positive irritation reactions were observed in five of the six animals with unwashed eyes which cleared in all animals by the 48-hour observation. In treated eyes receiving a washout after test material instillation, the test material produced only conjunctival irritation. All treated eyes in this group returned to a normal appearance by 72 hours after treatment. Positive irritation reactions were observed in two of the three animals with washed eyes which cleared in all animals by the 48-hour observation. Rinsing the eyes after treatment did not have a substantial effect on the severity and persistence of ocular irritation.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test material when evaluated for its primary eye irritation potential in rabbits, produced a corneal opacity in one animal and conjunctival irritation in all treated eyes that were unwashed after treatment. All treated eyes in this group returned to a normal appearance by 96 hours after treatment with the exception that two animals exhibited hair loss around the treated eye. Positive irritation reactions were observed in five of the six animals with unwashed eyes which cleared in all animals by the 48-hour observation.
- Executive summary:
The primary eye irritation potential of the test material was evaluated when 0.1 mL was instilled into one eye of each of nine rabbits (six with treated eyes unwashed and three with treated eyes washed for 1 minute starting 30 seconds after instillation). The test material produced a corneal opacity in one animal and conjunctival irritation in all unwashed eyes which cleared in all animals by 96 hours after treatment. Positive irritation reactions were observed in five of the six animals with unwashed eyes which cleared in all animals by the 48-hour observation. In treated eyes receiving a washout, the test material produced only conjunctival irritation which cleared in all animals by 72 hours after treatment. Positive irritation reactions were observed in two of the three animals with washed eyes which cleared in all animals by the 48-hour observation. Rinsing the eyes after treatment did not have a substantial effect on the severity and persistence of ocular irritation.
The mean value of the scores for cornea opacity, iris lesions, redness & oedema of the conjuctivae, for 24, 48 and 72 hours was calculated and was considered to be non-irritating according to the classification criteria.
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