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EC number: 236-216-9 | CAS number: 13241-33-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water: screening tests
Administrative data
Link to relevant study record(s)
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See 'Attached justification'. - Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- TEST MATERIAL
- Name of test material: neohesperidin
- IUPAC name: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxyhexopyranosyl)hexopyranoside
- Molecular formula: C28H34O15
- Molecular weight: 610.5606
- Smiles notation: COc1ccc(cc1O)C2CC(=O)c3c(O)cc(OC4OC(CO)C(O)C(O)C4OC5OC(C)C(O)C(O)C5O)cc3O2
- InChl: InChI= 1/C28H34O15/c1-10-21(33)23(35)25(37)27(39-10)43-26-24(36)22(34)19(9-29)42-28(26)40-12-6-14(31)20-15(32)8-17(41-18(20)7-12)11-3-4-16(38-2)13(30)5-11/h3-7,10,17,19,21-31,33-37H,8-9H2,1-2H3 - Key result
- Parameter:
- % degradation (O2 consumption)
- Sampling time:
- 28 d
- Remarks on result:
- other: ready biodegradable
- Remarks:
- Read-across from analogue substance (naringin).
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Based on the read-across approach, the target substance is expected to be readily biodegradable.
- Executive summary:
A 28-day ready aerobic biodegradability test in an aerobic aqueous medium with manometric respirometry method was performed on the analogue substance naringin, according to OECD 301F / EC C.4 – D manometric respirometry methods (GLP study). 100 mg/l of test item was inoculated with activated sludge (30 mg/L SS) and incubated under aerobic conditions in a closed respirometer flask at constant temperature (22 ± 2ºC) for 28 days. A blank test, a procedure test with reference substance (sodium acetate) and a toxicity test were run in parallel. In a toxicity test, containing both the test item and a reference item, on the 14th test day the biodegradation (based on ThOD) attained 54.1%. Thus, the analogue substance is not inhibitory.At the 28th day of the test the measured aerobic biodegradation of the test item attained 74.8%. Thus, the analogue substance is readily biodegradable. Based on the read-across approach, the target substance is expected to be readily biodegradable.
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Justification for type of information:
- REPORTING FORMAT FOR THE ANALOGUE APPROACH
See 'Attached justification'. - Reason / purpose for cross-reference:
- read-across source
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- TEST MATERIAL
- Name of test material: neohesperidin
- IUPAC name: 5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-oxo-3,4-dihydro-2H-chromen-7-yl 2-O-(6-deoxyhexopyranosyl)hexopyranoside
- Molecular formula: C28H34O15
- Molecular weight: 610.5606
- Smiles notation: COc1ccc(cc1O)C2CC(=O)c3c(O)cc(OC4OC(CO)C(O)C(O)C4OC5OC(C)C(O)C(O)C5O)cc3O2
- InChl: InChI= 1/C28H34O15/c1-10-21(33)23(35)25(37)27(39-10)43-26-24(36)22(34)19(9-29)42-28(26)40-12-6-14(31)20-15(32)8-17(41-18(20)7-12)11-3-4-16(38-2)13(30)5-11/h3-7,10,17,19,21-31,33-37H,8-9H2,1-2H3 - Key result
- Parameter:
- % degradation (O2 consumption)
- Sampling time:
- 28 d
- Remarks on result:
- other: ready biodegradable
- Remarks:
- Read-across from analogue substance (neohesperidin dihydrochalcone).
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- readily biodegradable
- Conclusions:
- Based on the read-across approach, the target substance is expected to be readily biodegradable.
- Executive summary:
A 28-day ready aerobic biodegradability test in an aerobic aqueous medium with manometric respirometry method was performed on the analogue substance neohesperidin dihydrochalcone, according to OECD 301F / EC C.4 – D manometric respirometry methods (GLP study). 100 mg/l of test item was inoculated with activated sludge (30 mg/L SS) and incubated under aerobic conditions in a closed respirometer flask at constant temperature (22 ± 2ºC) for 28 days. A blank test, a procedure test with reference substance (sodium acetate) and a toxicity test were run in parallel. In a toxicity test, containing both the test item and a reference item, on the 14th test day the biodegradation (based on ThOD) attained 42.7%. Thus, the analogue substance is not inhibitory.At the 28th day of the test the measured aerobic biodegradation of the test item attained 71%. Thus, the analogue substance is readily biodegradable. Based on the read-across approach, the target substance is expected to be readily biodegradable.
Referenceopen allclose all
Description of key information
Weight of evidence: Based on the read-across approach from two analogue substances, the target substance is readily biodegradable.
- Read-across from analogue substance. Source: Method according to OECD 301F / EU C.4 (Manometric respirometry), GLP study. At the 28th day of the test the measured aerobic biodegradation of the test item attained 74.8%. Thus, the test item is readily biodegradable. Based on the read-across approach, the target substance is expected to be readily biodegradable.
- Read-across from analogue substance. Source: Method according to OECD 301F / EU C.4 (Manometric respirometry), GLP study. At the 28th day of the test the measured aerobic biodegradation of the test item attained 71%. Thus, the test item is readily biodegradable. Based on the read-across approach, the target substance is expected to be readily biodegradable.
Key value for chemical safety assessment
- Biodegradation in water:
- readily biodegradable
Additional information
Weight of evidence:
- Read-across from analogue substance. A 28-day ready aerobic
biodegradability test in an aerobic aqueous medium with manometric
respirometry method was performed on the analogue substance naringin,
according to OECD 301F / EC C.4 – D manometric respirometry methods (GLP
study). 100 mg/l of test item was inoculated with activated sludge (30
mg/L SS) and incubated under aerobic conditions in a closed respirometer
flask at constant temperature (22 ± 2ºC) for 28 days. A blank test, a
procedure test with reference substance (sodium acetate) and a toxicity
test were run in parallel. In a toxicity test, containing both the test
item and a reference item, on the 14th test day the biodegradation
(based on ThOD) attained 54.1%. Thus, the analogue substance is not
inhibitory. At the 28th day of the test the measured aerobic
biodegradation of the test item attained 74.8%. Thus, the analogue
substance is readily biodegradable. Based on the read-across approach,
the target substance is expected to be readily biodegradable.
- Read-across from analogue substance. A 28-day ready aerobic biodegradability test in an aerobic aqueous medium with manometric respirometry method was performed on the analogue substance neohesperidin dihydrochalcone, according to OECD 301F / EC C.4 – D manometric respirometry methods (GLP study). 100 mg/l of test item was inoculated with activated sludge (30 mg/L SS) and incubated under aerobic conditions in a closed respirometer flask at constant temperature (22 ± 2ºC) for 28 days. A blank test, a procedure test with reference substance (sodium acetate) and a toxicity test were run in parallel. In a toxicity test, containing both the test item and a reference item, on the 14th test day the biodegradation (based on ThOD) attained 42.7%. Thus, the analogue substance is not inhibitory. At the 28th day of the test the measured aerobic biodegradation of the test item attained 71%. Thus, the analogue substance is readily biodegradable. Based on the read-across approach, the target substance is expected to be readily biodegradable.
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