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EC number: 221-110-7 | CAS number: 3006-82-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 978
- Report date:
- 1978
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- May 1981
- Deviations:
- yes
- Remarks:
- only limited data about analytics
- Principles of method if other than guideline:
- NA
- GLP compliance:
- no
- Test type:
- other: standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- tert-butyl 2-ethylperoxyhexanoate
- EC Number:
- 221-110-7
- EC Name:
- tert-butyl 2-ethylperoxyhexanoate
- Cas Number:
- 3006-82-4
- Molecular formula:
- C12H24O3
- IUPAC Name:
- tert-butyl 2-ethylhexaneperoxoate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Charles River CD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- - Weight: male 216 to 300 g; females 200 to 299 g
- Housing: wire-mesh cages
- Diet and water (e.g. ad libitum): Purina Laboratory Chow and water (ad libitum)
- Acclimation period: 4 hour
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- whole body
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- - Exposure apparatus: FMI LAB pump
- Exposure chamber volume: 160-liter cubical
- Rate of air: 8 L/min
- Pressure in air chamber: 10 psig
- Analytical verification of test atmosphere concentrations:
- no
- Remarks:
- The individual concentrations of the compound in the chamber atmosphere were calculated from the ratio of the rate of liquid dissemination to the rate of total chamber airflow.
- Duration of exposure:
- 4 h
- Concentrations:
- "metered" conc.: 9.2, 20.8, 46.5 and 103.4 mg/L
- No. of animals per sex per dose:
- 5 animals per sex per dose (total: 20 animals)
- Control animals:
- not specified
- Details on study design:
- 95 % confidence limits
Results and discussion
- Preliminary study:
- No preliminary study
Effect levelsopen allclose all
- Key result
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- 42.2 mg/L air
- 95% CL:
- 28.4 - 62.9
- Exp. duration:
- 4 h
- Key result
- Sex:
- female
- Dose descriptor:
- LC50
- Effect level:
- 42.2 mg/L air
- 95% CL:
- 25.2 - 70.7
- Exp. duration:
- 4 h
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- 42.2 mg/L air
- 95% CL:
- 30.8 - 58
- Exp. duration:
- 4 h
- Mortality:
- All animals (5 male, 5 females) died during the 14 day study period at the chamber concentration of 103.4 mg/L.
Further animals (6 animals) died at the chamber concentrations of 20.8 (1 female) and 46.5 mg/L (2 females, 3 male). - Clinical signs:
- other: Exposure concentration (103.4 mg/L): By 30 minutes of exposure, a nasal discharge was observed in all rats. Slight dyspnoea was observed in 4 rats by 3 hours of exposure and in all rats by 4 hours of exposure. Redness was observed in the ears and the paws
- Body weight:
- Exposure concentration (103.4 mg/L): A slight body weight loss was observed for day 1 postexposure.
Exposure concentration (46.5 mg/L): A slight body weight loss was observed for day 1 postexposure. This condition persisted for 7 days in the surviving rats.
Exposure concentration (20.8 mg/L): A slight body weight loss was observed in all rats for day 1 postexposure.
Exposure concentration (9.2 mg/L): A slight body weight loss was observed for day 1 postexposure which persisted for 5 days for 3 male rats and 14 days for 1 female rat. - Gross pathology:
- Exposure concentration (103.4 mg/L): Necropsy of the rats revealed red patches in the lungs.
Exposure concentration (46.5 mg/L): Necropsy of the rats which died revealed pink lungs with dark red patches.
Exposure concentration (20.8 mg/L): Necropsy of the 1 female rat revealed 2 large red patches on the left lung. - Other findings:
- NA
Any other information on results incl. tables
No remarks
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The LC50 was calculated to be 42.2 mg/L with 95% confidence limits of 30.8 and 58.0 mg/L.
- Executive summary:
Four groups of male and female rats were exposed to the aerosol and vapour atmospheres of tert.-Butylperoxy- 2-ethylhexanoat. The four "metered" concentrations were 103.4, 46.5, 20.8 and 9.2 mg/L, respectively. During the 4 -hour exposures, nasal discharge and slight dyspnoea were observed in all groups of rats. Redness of ears and paws developed shortly after exposure in all rats exposed to 103.4 and 46.5 mg/L. Death occurred in all groups on 1 or 2 days postexposure at concentrations above 9.2 mg/L.
The LC50 was calculated to be 42.2 mg/L with 95% confidence limits of 30.8 and 58.0 mg/L.
Necropsy of the rats that died during the observation period revealed red patches in the lungs.
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