Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 273-234-6 | CAS number: 68953-96-8 This substance is identified by SDA Substance Name: C11-C13 branched alkyl benzene sulfonic acid calcium salt and SDA Reporting Number: 25-097-06.
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study in peer-reviewed publication conducted by experienced testing laboratory.
Data source
Reference
- Reference Type:
- publication
- Title:
- Metabolism of linear alkylate sulfonate and alkyl benzene sulfonate in albino rats
- Author:
- Michael, W.R.
- Year:
- 1 968
- Bibliographic source:
- Toxicol. Appl. Pharmacol. 12:473-485
Materials and methods
- Objective of study:
- metabolism
- Principles of method if other than guideline:
- The absorption, distribution, metabolism and elimination of Branched alkylbenzene sulfonate (radioactively labeled with 35S) were studied in male Charles River rats. The substance was administered as an aqueous solution.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Branched Alkyl benzene sulfonate (ABS)
- IUPAC Name:
- Branched Alkyl benzene sulfonate (ABS)
- Details on test material:
- Branched alkylbenzene sulfonate (ABS); alkyl chain length predominately C12 with indications of trace amounts of C11 and C13. On the average, the alkyl chain was 8 to 9 carbon atoms in length and contained 3 to 4 methyl branch points.
Constituent 1
- Radiolabelling:
- yes
- Remarks:
- (radioactively labeled with 35S)
Test animals
- Species:
- rat
- Strain:
- other: Charles River albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- The animals were housed in individual cages which permitted the separate collection of urine and feces. Food and water were provided ad libitum after dosing.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on exposure:
- Male rats (150-200 g) were fasted for 16 hours and given orally an aqueous solution containing AB35S. The dose was given in 1.0 mL volume. The urine was collected under toluene, removed daily, and refrigerated until it could be examined. The feces were removed each day and allowed to dry at room temperature. At the termination of the study, the animals were killed and selected organs and tissues were taken for radioassay.
Also, the route of absorption was determined by oral feeding of 40 mg of ABS to thoracic duct-cannulated rats. The lymph was collected from each animal in a single 42-hour fraction.
The enterohepatic circulation of the sufactant was quantifed by oral feeding of 1.2 mg of ABS to bile duct-cannulated rats and to rats prepared in a manner similar to the dual rat study described by Boquet and Fromageot. A cannula was inserted into the proximal end of the bil duct of Rat A and into the distal end of the bile duct in Rat B such that the bile from Rat A could flow through the cannula into the bile duct, and finally into the intestine of Rat B. A second cannula was inserted into the proximal end of the bile duct of Rat B so that this bile could be collected. AB35S was fed orally to Rat A. Urine and feces of Rats A and B and bile of Rat B were collected for 90 hours after dosing. - Duration and frequency of treatment / exposure:
- See details of exposure section
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.6, 1.2, and 40.0 mg (averages of three animals per dose) for the excretion test, 1.2 mg/rat for the absorption and enterohepatic circulation tests.
- No. of animals per sex per dose / concentration:
- Three or five males per dose for the excretion test, six males for the absorption and enterohepatic tests.
- Control animals:
- not specified
Results and discussion
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- The compound was readily absorbed from the gastrointestinal tract (80-90% of the dose).
- Details on distribution in tissues:
- Primarily excreted in the bile.
- Details on excretion:
- Most of the absorbed 35S from orally administered AB35S was eliminated within 72 hours and 80-90% of the absorbed dose was eliminated in the bile.
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- The metabolites isolated from the bile were found to be sulfophenyl carboxylates. One series of compounds (ABS-I) was found to contain two double bonds in the alkyl chain. Neither of these double bonds appear to be alpha-beta to the carboxyl group. The other fraction (ABS-II) seemed to contain only a saturated sulfophenyl carboxylate with eleven carbons in the carboxylate chain.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): no bioaccumulation potential based on study results
Branched alkylbenzene sulfonate (ABS) is readily absorbed by the gastrointestinal tract and rapidly excreted with its metabolites, primarily in the bile. - Executive summary:
The absorption, distribution, metabolism and elimination of Branched alkylbenzene sulfonate (radioactively labeled with 35S) were studied in male Charles River rats. The substance was readily absorbed by the gastrointestinal tract and rapidly metabolized and excreted in the bile.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.